CFLAR protein (Pongo abelii) - STRING interaction network

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CFLAR

CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...] (480 aa)

Predicted Functional Partners:

FADD

0.998

CASP8

0.998

CASP10

0.997

ITCH

0.993

TNFRSF10A

0.973

TNFSF10

0.966

FAS

0.941

TNFRSF10B

0.938

ATG3

0.932

RIPK1

0.926

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG3	CFLAR	ENSPPYP00000015148	ENSPPYP00000014600	Autophagy-related protein 3.	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	0.932
CASP10	CASP8	ENSPPYP00000014602	ENSPPYP00000014605	CASP10 isoform 3; Belongs to the peptidase C14A family.	CASP8 isoform 1; Belongs to the peptidase C14A family.	0.997
CASP10	CFLAR	ENSPPYP00000014602	ENSPPYP00000014600	CASP10 isoform 3; Belongs to the peptidase C14A family.	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	0.997
CASP10	FADD	ENSPPYP00000014602	ENSPPYP00000003427	CASP10 isoform 3; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP10	FAS	ENSPPYP00000014602	ENSPPYP00000002850	CASP10 isoform 3; Belongs to the peptidase C14A family.	FAS isoform 1.	0.956
CASP10	RIPK1	ENSPPYP00000014602	ENSPPYP00000018096	CASP10 isoform 3; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.966
CASP10	TNFRSF10A	ENSPPYP00000014602	ENSPPYP00000020658	CASP10 isoform 3; Belongs to the peptidase C14A family.	TNFRSF10A isoform 1.	0.778
CASP10	TNFRSF10B	ENSPPYP00000014602	ENSPPYP00000020655	CASP10 isoform 3; Belongs to the peptidase C14A family.	TNFRSF10B isoform 3.	0.872
CASP10	TNFSF10	ENSPPYP00000014602	ENSPPYP00000015988	CASP10 isoform 3; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member.	0.883
CASP8	CASP10	ENSPPYP00000014605	ENSPPYP00000014602	CASP8 isoform 1; Belongs to the peptidase C14A family.	CASP10 isoform 3; Belongs to the peptidase C14A family.	0.997
CASP8	CFLAR	ENSPPYP00000014605	ENSPPYP00000014600	CASP8 isoform 1; Belongs to the peptidase C14A family.	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	0.998
CASP8	FADD	ENSPPYP00000014605	ENSPPYP00000003427	CASP8 isoform 1; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	FAS	ENSPPYP00000014605	ENSPPYP00000002850	CASP8 isoform 1; Belongs to the peptidase C14A family.	FAS isoform 1.	0.990
CASP8	RIPK1	ENSPPYP00000014605	ENSPPYP00000018096	CASP8 isoform 1; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.999
CASP8	TNFRSF10A	ENSPPYP00000014605	ENSPPYP00000020658	CASP8 isoform 1; Belongs to the peptidase C14A family.	TNFRSF10A isoform 1.	0.976
CASP8	TNFRSF10B	ENSPPYP00000014605	ENSPPYP00000020655	CASP8 isoform 1; Belongs to the peptidase C14A family.	TNFRSF10B isoform 3.	0.979
CASP8	TNFSF10	ENSPPYP00000014605	ENSPPYP00000015988	CASP8 isoform 1; Belongs to the peptidase C14A family.	Tumor necrosis factor ligand superfamily member.	0.978
CFLAR	ATG3	ENSPPYP00000014600	ENSPPYP00000015148	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	Autophagy-related protein 3.	0.932
CFLAR	CASP10	ENSPPYP00000014600	ENSPPYP00000014602	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	CASP10 isoform 3; Belongs to the peptidase C14A family.	0.997
CFLAR	CASP8	ENSPPYP00000014600	ENSPPYP00000014605	CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...]	CASP8 isoform 1; Belongs to the peptidase C14A family.	0.998

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