node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO1 | ACO2 | ENSPPYP00000021456 | ENSPPYP00000013248 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 0.926 |
ACO1 | CS | ENSPPYP00000021456 | ENSPPYP00000005303 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | Citrate synthase, mitochondrial isoform X1. | 0.997 |
ACO1 | IDH1 | ENSPPYP00000021456 | ENSPPYP00000014668 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP] cytoplasmic. | 0.993 |
ACO1 | IDH2 | ENSPPYP00000021456 | ENSPPYP00000007685 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.993 |
ACO1 | IDH3A | ENSPPYP00000021456 | ENSPPYP00000007593 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.970 |
ACO1 | IDH3B | ENSPPYP00000021456 | ENSPPYP00000012103 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.966 |
ACO1 | IDH3G | ENSPPYP00000021456 | ENSPPYP00000023340 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | 0.966 |
ACO1 | OGDH | ENSPPYP00000021456 | ENSPPYP00000019712 | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- Co [...] | 0.460 |
ACO2 | ACO1 | ENSPPYP00000013248 | ENSPPYP00000021456 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | 0.926 |
ACO2 | CS | ENSPPYP00000013248 | ENSPPYP00000005303 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Citrate synthase, mitochondrial isoform X1. | 0.999 |
ACO2 | GLUD1 | ENSPPYP00000013248 | ENSPPYP00000003292 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Glutamate dehydrogenase 1; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.402 |
ACO2 | IDH1 | ENSPPYP00000013248 | ENSPPYP00000014668 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP] cytoplasmic. | 0.993 |
ACO2 | IDH2 | ENSPPYP00000013248 | ENSPPYP00000007685 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.993 |
ACO2 | IDH3A | ENSPPYP00000013248 | ENSPPYP00000007593 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.997 |
ACO2 | IDH3B | ENSPPYP00000013248 | ENSPPYP00000012103 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. | 0.993 |
ACO2 | IDH3G | ENSPPYP00000013248 | ENSPPYP00000023340 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. | 0.989 |
ACO2 | OGDH | ENSPPYP00000013248 | ENSPPYP00000019712 | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- Co [...] | 0.919 |
CS | ACO1 | ENSPPYP00000005303 | ENSPPYP00000021456 | Citrate synthase, mitochondrial isoform X1. | ACO1 isoform 1; Belongs to the aconitase/IPM isomerase family. | 0.997 |
CS | ACO2 | ENSPPYP00000005303 | ENSPPYP00000013248 | Citrate synthase, mitochondrial isoform X1. | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. | 0.999 |
CS | GLUD1 | ENSPPYP00000005303 | ENSPPYP00000003292 | Citrate synthase, mitochondrial isoform X1. | Glutamate dehydrogenase 1; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.910 |