| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASL | ASS1 | ENSPPYP00000019643 | ENSPPYP00000022070 | Argininosuccinate lyase isoform X1. | ASS1 isoform 1. | 0.995 |
| ASL | CAD | ENSPPYP00000019643 | ENSPPYP00000014025 | Argininosuccinate lyase isoform X1. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.810 |
| ASL | CPS1 | ENSPPYP00000019643 | ENSPPYP00000014680 | Argininosuccinate lyase isoform X1. | Carbamoyl-phosphate synthase 1. | 0.876 |
| ASL | OTC | ENSPPYP00000019643 | ENSPPYP00000022656 | Argininosuccinate lyase isoform X1. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.849 |
| ASS1 | ASL | ENSPPYP00000022070 | ENSPPYP00000019643 | ASS1 isoform 1. | Argininosuccinate lyase isoform X1. | 0.995 |
| ASS1 | CAD | ENSPPYP00000022070 | ENSPPYP00000014025 | ASS1 isoform 1. | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | 0.971 |
| ASS1 | CPS1 | ENSPPYP00000022070 | ENSPPYP00000014680 | ASS1 isoform 1. | Carbamoyl-phosphate synthase 1. | 0.978 |
| ASS1 | OTC | ENSPPYP00000022070 | ENSPPYP00000022656 | ASS1 isoform 1. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.992 |
| CAD | ASL | ENSPPYP00000014025 | ENSPPYP00000019643 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Argininosuccinate lyase isoform X1. | 0.810 |
| CAD | ASS1 | ENSPPYP00000014025 | ENSPPYP00000022070 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | ASS1 isoform 1. | 0.971 |
| CAD | CPS1 | ENSPPYP00000014025 | ENSPPYP00000014680 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Carbamoyl-phosphate synthase 1. | 0.902 |
| CAD | GLS | ENSPPYP00000014025 | ENSPPYP00000014554 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | GLS isoform 1. | 0.947 |
| CAD | GLS2 | ENSPPYP00000014025 | ENSPPYP00000005314 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | GLS2 isoform 5. | 0.918 |
| CAD | GLUD1 | ENSPPYP00000014025 | ENSPPYP00000003292 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate dehydrogenase 1; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.548 |
| CAD | GLUD2 | ENSPPYP00000014025 | ENSPPYP00000023161 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamate dehydrogenase 2, mitochondrial. | 0.548 |
| CAD | GLUL | ENSPPYP00000014025 | ENSPPYP00000000500 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Glutamine synthetase. | 0.959 |
| CAD | OTC | ENSPPYP00000014025 | ENSPPYP00000022656 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.989 |
| CAD | SIRT5 | ENSPPYP00000014025 | ENSPPYP00000018164 | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinyla [...] | 0.708 |
| CPS1 | ASL | ENSPPYP00000014680 | ENSPPYP00000019643 | Carbamoyl-phosphate synthase 1. | Argininosuccinate lyase isoform X1. | 0.876 |
| CPS1 | ASS1 | ENSPPYP00000014680 | ENSPPYP00000022070 | Carbamoyl-phosphate synthase 1. | ASS1 isoform 1. | 0.978 |
