| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABRAXAS1 | BAP1 | ENSPPYP00000016637 | ENSPPYP00000015452 | Abraxas 1, BRCA1 A complex subunit. | Ubiquitin carboxyl-terminal hydrolase. | 0.432 |
| ABRAXAS1 | BARD1 | ENSPPYP00000016637 | ENSPPYP00000014687 | Abraxas 1, BRCA1 A complex subunit. | BARD1 isoform 3. | 0.986 |
| ABRAXAS1 | BRCA1 | ENSPPYP00000016637 | ENSPPYP00000009402 | Abraxas 1, BRCA1 A complex subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.997 |
| ABRAXAS1 | CR201_G0002293 | ENSPPYP00000016637 | ENSPPYP00000010169 | Abraxas 1, BRCA1 A complex subunit. | RBBP8 isoform 3. | 0.667 |
| ABRAXAS1 | NBN | ENSPPYP00000016637 | ENSPPYP00000021011 | Abraxas 1, BRCA1 A complex subunit. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] | 0.642 |
| ABRAXAS1 | RAD50 | ENSPPYP00000016637 | ENSPPYP00000017630 | Abraxas 1, BRCA1 A complex subunit. | T0008522 isoform 4. | 0.681 |
| BAP1 | ABRAXAS1 | ENSPPYP00000015452 | ENSPPYP00000016637 | Ubiquitin carboxyl-terminal hydrolase. | Abraxas 1, BRCA1 A complex subunit. | 0.432 |
| BAP1 | BARD1 | ENSPPYP00000015452 | ENSPPYP00000014687 | Ubiquitin carboxyl-terminal hydrolase. | BARD1 isoform 3. | 0.970 |
| BAP1 | BRCA1 | ENSPPYP00000015452 | ENSPPYP00000009402 | Ubiquitin carboxyl-terminal hydrolase. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.838 |
| BAP1 | NBN | ENSPPYP00000015452 | ENSPPYP00000021011 | Ubiquitin carboxyl-terminal hydrolase. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] | 0.451 |
| BAP1 | RAD50 | ENSPPYP00000015452 | ENSPPYP00000017630 | Ubiquitin carboxyl-terminal hydrolase. | T0008522 isoform 4. | 0.516 |
| BARD1 | ABRAXAS1 | ENSPPYP00000014687 | ENSPPYP00000016637 | BARD1 isoform 3. | Abraxas 1, BRCA1 A complex subunit. | 0.986 |
| BARD1 | BAP1 | ENSPPYP00000014687 | ENSPPYP00000015452 | BARD1 isoform 3. | Ubiquitin carboxyl-terminal hydrolase. | 0.970 |
| BARD1 | BRCA1 | ENSPPYP00000014687 | ENSPPYP00000009402 | BARD1 isoform 3. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
| BARD1 | BRCA2 | ENSPPYP00000014687 | ENSPPYP00000005997 | BARD1 isoform 3. | BRCA2 isoform 1. | 0.985 |
| BARD1 | BRIP1 | ENSPPYP00000014687 | ENSPPYP00000009883 | BARD1 isoform 3. | BRCA1 interacting protein C-terminal helicase 1. | 0.985 |
| BARD1 | CR201_G0002293 | ENSPPYP00000014687 | ENSPPYP00000010169 | BARD1 isoform 3. | RBBP8 isoform 3. | 0.992 |
| BARD1 | NBN | ENSPPYP00000014687 | ENSPPYP00000021011 | BARD1 isoform 3. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] | 0.971 |
| BARD1 | RAD50 | ENSPPYP00000014687 | ENSPPYP00000017630 | BARD1 isoform 3. | T0008522 isoform 4. | 0.971 |
| BARD1 | RAD51 | ENSPPYP00000014687 | ENSPPYP00000007198 | BARD1 isoform 3. | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] | 0.973 |
