| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACSL1 | ACSL3 | ENSPPYP00000017025 | ENSPPYP00000024216 | ACSL1 isoform 4. | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | 0.819 |
| ACSL1 | ACSL5 | ENSPPYP00000017025 | ENSPPYP00000003093 | ACSL1 isoform 4. | ACSL5 isoform 4. | 0.647 |
| ACSL1 | CPT1A | ENSPPYP00000017025 | ENSPPYP00000003441 | ACSL1 isoform 4. | CPT1A isoform 3; Belongs to the carnitine/choline acetyltransferase family. | 0.957 |
| ACSL1 | CPT1B | ENSPPYP00000017025 | ENSPPYP00000013379 | ACSL1 isoform 4. | Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. | 0.936 |
| ACSL1 | CPT1C | ENSPPYP00000017025 | ENSPPYP00000011791 | ACSL1 isoform 4. | CPT1C isoform 2; Belongs to the carnitine/choline acetyltransferase family. | 0.934 |
| ACSL1 | FASN | ENSPPYP00000017025 | ENSPPYP00000009843 | ACSL1 isoform 4. | FASN isoform 1. | 0.961 |
| ACSL1 | LPL | ENSPPYP00000017025 | ENSPPYP00000020617 | ACSL1 isoform 4. | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.888 |
| ACSL1 | MGLL | ENSPPYP00000017025 | ENSPPYP00000015033 | ACSL1 isoform 4. | Monoglyceride lipase. | 0.846 |
| ACSL1 | PPT1 | ENSPPYP00000017025 | ENSPPYP00000001728 | ACSL1 isoform 4. | Palmitoyl-protein thioesterase 1. | 0.831 |
| ACSL1 | PPT2 | ENSPPYP00000017025 | ENSPPYP00000018431 | ACSL1 isoform 4. | PPT2-EGFL8 isoform 1. | 0.831 |
| ACSL3 | ACSL1 | ENSPPYP00000024216 | ENSPPYP00000017025 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | ACSL1 isoform 4. | 0.819 |
| ACSL3 | ACSL5 | ENSPPYP00000024216 | ENSPPYP00000003093 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | ACSL5 isoform 4. | 0.788 |
| ACSL3 | CPT1A | ENSPPYP00000024216 | ENSPPYP00000003441 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | CPT1A isoform 3; Belongs to the carnitine/choline acetyltransferase family. | 0.935 |
| ACSL3 | CPT1B | ENSPPYP00000024216 | ENSPPYP00000013379 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. | 0.923 |
| ACSL3 | CPT1C | ENSPPYP00000024216 | ENSPPYP00000011791 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | CPT1C isoform 2; Belongs to the carnitine/choline acetyltransferase family. | 0.923 |
| ACSL3 | FASN | ENSPPYP00000024216 | ENSPPYP00000009843 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | FASN isoform 1. | 0.941 |
| ACSL3 | LPL | ENSPPYP00000024216 | ENSPPYP00000020617 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.884 |
| ACSL3 | MGLL | ENSPPYP00000024216 | ENSPPYP00000015033 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | Monoglyceride lipase. | 0.830 |
| ACSL3 | PPT1 | ENSPPYP00000024216 | ENSPPYP00000001728 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | Palmitoyl-protein thioesterase 1. | 0.838 |
| ACSL3 | PPT2 | ENSPPYP00000024216 | ENSPPYP00000018431 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] | PPT2-EGFL8 isoform 1. | 0.838 |
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