STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DGKDDiacylglycerol kinase. (1106 aa)    
Predicted Functional Partners:
ESPL1
ESPL1 isoform 1.
   
 
 0.655
TMEM59
Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
      
 0.652
UBB
UBB isoform 2.
      
 0.591
ASPM
ASPM isoform 2.
   
  
 0.584
ATG101
ATG101 isoform 1.
      
 0.584
NDC80
NDC80 kinetochore complex component.
   
  
 0.568
CA5B
Carbonic anhydrase 5B; Belongs to the alpha-carbonic anhydrase family.
   
  
 0.554
CR201_G0046053
NUSAP1 isoform 6.
   
  
 0.548
TTK
TTK isoform 4.
   
  
 0.547
CA8
Carbonic anhydrase 8; Belongs to the alpha-carbonic anhydrase family.
      
 0.540
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.