STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CR201_G0049379GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (395 aa)    
Predicted Functional Partners:
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
    
 0.843
SLIT3
SLIT3 isoform 2.
    
 0.792
SLIT2
SLIT2 isoform 5.
    
 0.788
COL18A1
COL18A1 isoform 3.
    
 
 0.771
CR201_G0021182
NOTUM isoform 1.
    
 0.741
FGF2
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.695
PLAC1
Placenta enriched 1.
      
 0.681
CR201_G0011084
CD44 isoform 1.
    
 
 0.680
EPS8
Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...]
      
 0.679
FGF17
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.658
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.