STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BOKBCL2 family apoptosis regulator BOK. (212 aa)    
Predicted Functional Partners:
MCL1
MCL1 apoptosis regulator, BCL2 family member.
    
 
 0.824
BCL2L11
BCL2L11 isoform 4.
    
 0.760
BAD
BCL2 associated agonist of cell death.
   
 0.707
PMAIP1
Phorbol-12-myristate-13-acetate-induced protein 1.
    
 0.701
BCL2
BCL2 isoform 1.
      
 0.670
SORL1
SORL1 isoform 1.
      
 0.665
TSNARE1
TSNARE1 isoform 1.
   
  
 0.664
PSEN2
Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...]
    
 
 0.642
BID
BID isoform 12.
   
 0.623
BID-2
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 0.623
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.