STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CR201_G0032337-2CYP27A1 isoform 5. (382 aa)    
Predicted Functional Partners:
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
  
 
 0.983
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 0.951
CYP7B1
Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.
  
  
0.947
SLC27A5
Solute carrier family 27 member 5.
   
 
 0.939
CYP8B1
Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family.
  
  
0.933
AKR1C4
Aldo-keto reductase family 1 member C3 homolog; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
   
 
 0.921
DHCR7
DHCR7 isoform 1.
   
 0.905
DHCR24
DHCR24 isoform 1.
   
 0.850
SOAT1
O-acyltransferase.
   
 
 0.831
LIPA
Lipase; Belongs to the AB hydrolase superfamily. Lipase family.
  
 0.830
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.