| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CMPK1 | GART | ENSPPYP00000001599 | ENSPPYP00000012701 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.420 |
| CMPK1 | NT5E | ENSPPYP00000001599 | ENSPPYP00000018827 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.907 |
| CMPK1 | UCK1 | ENSPPYP00000001599 | ENSPPYP00000022094 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.967 |
| CMPK1 | UCK2 | ENSPPYP00000001599 | ENSPPYP00000000659 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.959 |
| CMPK1 | UCKL1 | ENSPPYP00000001599 | ENSPPYP00000012572 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.939 |
| CMPK1 | UMPS | ENSPPYP00000001599 | ENSPPYP00000015062 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Orotidine 5'-phosphate decarboxylase; In the C-terminal section; belongs to the OMP decarboxylase family. | 0.965 |
| CR201_G0040093 | DHODH | ENSPPYP00000014359 | ENSPPYP00000008492 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 0.656 |
| CR201_G0040093 | DPYD | ENSPPYP00000014359 | ENSPPYP00000001308 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). | 0.967 |
| CR201_G0040093 | NT5E | ENSPPYP00000014359 | ENSPPYP00000018827 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.964 |
| CR201_G0040093 | UCK1 | ENSPPYP00000014359 | ENSPPYP00000022094 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.971 |
| CR201_G0040093 | UCK2 | ENSPPYP00000014359 | ENSPPYP00000000659 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.947 |
| CR201_G0040093 | UCKL1 | ENSPPYP00000014359 | ENSPPYP00000012572 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.949 |
| CR201_G0040093 | UMPS | ENSPPYP00000014359 | ENSPPYP00000015062 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | Orotidine 5'-phosphate decarboxylase; In the C-terminal section; belongs to the OMP decarboxylase family. | 0.947 |
| CR201_G0040093 | UPP1 | ENSPPYP00000014359 | ENSPPYP00000019692 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.990 |
| DHODH | CR201_G0040093 | ENSPPYP00000008492 | ENSPPYP00000014359 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.656 |
| DHODH | GART | ENSPPYP00000008492 | ENSPPYP00000012701 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.709 |
| DHODH | NT5E | ENSPPYP00000008492 | ENSPPYP00000018827 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. | 0.652 |
| DHODH | UCK2 | ENSPPYP00000008492 | ENSPPYP00000000659 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.495 |
| DHODH | UCKL1 | ENSPPYP00000008492 | ENSPPYP00000012572 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Uridine-cytidine kinase; Belongs to the uridine kinase family. | 0.502 |
| DHODH | UMPS | ENSPPYP00000008492 | ENSPPYP00000015062 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | Orotidine 5'-phosphate decarboxylase; In the C-terminal section; belongs to the OMP decarboxylase family. | 0.998 |
