PLA1A protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PLA1A

Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity). (455 aa)

Predicted Functional Partners:

PTDSS2

0.922

PISD

0.921

MBOAT1

0.909

LPCAT3

0.905

MBOAT2

0.905

LPCAT4

0.903

CR201_G0005946

0.719

MAPK3

0.689

MAPK1

0.689

LPAR3

0.566

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0005946	LPAR3	ENSPPYP00000004550	ENSPPYP00000001390	POU domain protein.	Lysophosphatidic acid receptor 3.	0.550
CR201_G0005946	PLA1A	ENSPPYP00000004550	ENSPPYP00000015111	POU domain protein.	Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity).	0.719
LPAR3	CR201_G0005946	ENSPPYP00000001390	ENSPPYP00000004550	Lysophosphatidic acid receptor 3.	POU domain protein.	0.550
LPAR3	PLA1A	ENSPPYP00000001390	ENSPPYP00000015111	Lysophosphatidic acid receptor 3.	Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity).	0.566
LPCAT3	LPCAT4	ENSPPYP00000004805	ENSPPYP00000007155	LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family.	LPCAT4 isoform 1.	0.946
LPCAT3	MBOAT1	ENSPPYP00000004805	ENSPPYP00000018192	LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family.	Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family.	0.909
LPCAT3	MBOAT2	ENSPPYP00000004805	ENSPPYP00000014144	LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family.	MBOAT2 isoform 1; Belongs to the membrane-bound acyltransferase family.	0.928
LPCAT3	PISD	ENSPPYP00000004805	ENSPPYP00000013093	LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family.	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.	0.904
LPCAT3	PLA1A	ENSPPYP00000004805	ENSPPYP00000015111	LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family.	Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity).	0.905
LPCAT3	PTDSS2	ENSPPYP00000004805	ENSPPYP00000003331	LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family.	Phosphatidylserine synthase 2.	0.901
LPCAT4	LPCAT3	ENSPPYP00000007155	ENSPPYP00000004805	LPCAT4 isoform 1.	LPCAT3 isoform 2; Belongs to the membrane-bound acyltransferase family.	0.946
LPCAT4	MBOAT1	ENSPPYP00000007155	ENSPPYP00000018192	LPCAT4 isoform 1.	Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family.	0.934
LPCAT4	MBOAT2	ENSPPYP00000007155	ENSPPYP00000014144	LPCAT4 isoform 1.	MBOAT2 isoform 1; Belongs to the membrane-bound acyltransferase family.	0.952
LPCAT4	PISD	ENSPPYP00000007155	ENSPPYP00000013093	LPCAT4 isoform 1.	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.	0.915
LPCAT4	PLA1A	ENSPPYP00000007155	ENSPPYP00000015111	LPCAT4 isoform 1.	Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity).	0.903
LPCAT4	PTDSS2	ENSPPYP00000007155	ENSPPYP00000003331	LPCAT4 isoform 1.	Phosphatidylserine synthase 2.	0.901
MAPK1	MAPK3	ENSPPYP00000023664	ENSPPYP00000008184	Mitogen-activated protein kinase 1 isoform X1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.996
MAPK1	PLA1A	ENSPPYP00000023664	ENSPPYP00000015111	Mitogen-activated protein kinase 1 isoform X1.	Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity).	0.689
MAPK3	MAPK1	ENSPPYP00000008184	ENSPPYP00000023664	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase 1 isoform X1.	0.996
MAPK3	PLA1A	ENSPPYP00000008184	ENSPPYP00000015111	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity).	0.689

page 1 of 3

Server load: medium (72%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About