STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD47Leukocyte surface antigen CD47; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integ [...] (324 aa)    
Predicted Functional Partners:
SIRPA
SIRPA isoform 2.
   
 0.999
CR201_G0018437
SIRPG isoform 1.
   
 0.994
THBS1
Thrombospondin 1.
   
 
 0.989
THBS2
THBS2 isoform 1.
   
 
 0.962
SIRPB1
SIRPG isoform 2.
   
 0.902
CD36
CD36 isoform 15; Belongs to the CD36 family.
   
  
 0.866
SCARB2
SCARB2 isoform 16; Belongs to the CD36 family.
   
  
 0.829
PTPRC
PTPRC isoform 2.
   
 
 0.825
SCARB1
SCARB1 isoform 7; Belongs to the CD36 family.
   
  
 0.824
RHAG
RHAG isoform 3.
      
 0.821
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: medium (44%) [HD]