STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)    
Predicted Functional Partners:
SLC6A11
Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
  
 
 
0.911
STX1A
Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...]
   
 
 0.737
OLIG3
Oligodendrocyte transcription factor 3.
   
  
 0.730
GABRD
GABRD isoform 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.721
UBASH3B
UBASH3B isoform 1.
   
  
 0.712
PDGFC
Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.
      
 0.708
ITPKA
Kinase; Belongs to the inositol phosphokinase (IPK) family.
      
 0.705
SPRY1
Sprouty RTK signaling antagonist 1.
      
 0.703
ABI2
ABI2 isoform 1.
      
 0.699
GABRA5
Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.695
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.