GHRL protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRP	GCG	ENSPPYP00000008427	ENSPPYP00000014379	Agouti related neuropeptide.	GCG isoform 1.	0.451
AGRP	GHRL	ENSPPYP00000008427	ENSPPYP00000015270	Agouti related neuropeptide.	Ghrelin and obestatin prepropeptide.	0.801
AGRP	GHSR	ENSPPYP00000008427	ENSPPYP00000015987	Agouti related neuropeptide.	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.541
AGRP	INS-IGF2	ENSPPYP00000008427	ENSPPYP00000003393	Agouti related neuropeptide.	INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.596
AGRP	LEP	ENSPPYP00000008427	ENSPPYP00000020162	Agouti related neuropeptide.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.794
AGRP	MBOAT4	ENSPPYP00000008427	ENSPPYP00000020721	Agouti related neuropeptide.	MBOAT4 isoform 1; Belongs to the membrane-bound acyltransferase family.	0.480
FAP	GCG	ENSPPYP00000014380	ENSPPYP00000014379	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	GCG isoform 1.	0.623
FAP	GHRL	ENSPPYP00000014380	ENSPPYP00000015270	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Ghrelin and obestatin prepropeptide.	0.803
FAP	INS-IGF2	ENSPPYP00000014380	ENSPPYP00000003393	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.645
FAP	LEP	ENSPPYP00000014380	ENSPPYP00000020162	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.695
FAP	PCSK1	ENSPPYP00000014380	ENSPPYP00000017493	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	PCSK1 isoform 1; Belongs to the peptidase S8 family.	0.697
GCG	AGRP	ENSPPYP00000014379	ENSPPYP00000008427	GCG isoform 1.	Agouti related neuropeptide.	0.451
GCG	FAP	ENSPPYP00000014379	ENSPPYP00000014380	GCG isoform 1.	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	0.623
GCG	GHRL	ENSPPYP00000014379	ENSPPYP00000015270	GCG isoform 1.	Ghrelin and obestatin prepropeptide.	0.915
GCG	IGF1	ENSPPYP00000014379	ENSPPYP00000005572	GCG isoform 1.	Insulin like growth factor 1.	0.474
GCG	INS-IGF2	ENSPPYP00000014379	ENSPPYP00000003393	GCG isoform 1.	INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.783
GCG	LEP	ENSPPYP00000014379	ENSPPYP00000020162	GCG isoform 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.896
GCG	PCSK1	ENSPPYP00000014379	ENSPPYP00000017493	GCG isoform 1.	PCSK1 isoform 1; Belongs to the peptidase S8 family.	0.763
GHRL	AGRP	ENSPPYP00000015270	ENSPPYP00000008427	Ghrelin and obestatin prepropeptide.	Agouti related neuropeptide.	0.801
GHRL	FAP	ENSPPYP00000015270	ENSPPYP00000014380	Ghrelin and obestatin prepropeptide.	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	0.803