| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IL1R1 | IRAK1 | ENSPPYP00000013505 | ENSPPYP00000023353 | Interleukin 1 receptor type 1. | Interleukin 1 receptor associated kinase 1. | 0.980 |
| IL1R1 | IRAK2 | ENSPPYP00000013505 | ENSPPYP00000015274 | Interleukin 1 receptor type 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.877 |
| IL1R1 | IRAK4 | ENSPPYP00000013505 | ENSPPYP00000005053 | Interleukin 1 receptor type 1. | IRAK4 isoform 6. | 0.891 |
| IL1R1 | MYD88 | ENSPPYP00000013505 | ENSPPYP00000015673 | Interleukin 1 receptor type 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.984 |
| IL1R1 | TIRAP | ENSPPYP00000013505 | ENSPPYP00000004627 | Interleukin 1 receptor type 1. | TIR domain containing adaptor protein. | 0.541 |
| IL1R1 | TOLLIP | ENSPPYP00000013505 | ENSPPYP00000003370 | Interleukin 1 receptor type 1. | Toll interacting protein. | 0.876 |
| IL1R1 | TRAF6 | ENSPPYP00000013505 | ENSPPYP00000003845 | Interleukin 1 receptor type 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.951 |
| IRAK1 | IL1R1 | ENSPPYP00000023353 | ENSPPYP00000013505 | Interleukin 1 receptor associated kinase 1. | Interleukin 1 receptor type 1. | 0.980 |
| IRAK1 | IRAK2 | ENSPPYP00000023353 | ENSPPYP00000015274 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.991 |
| IRAK1 | IRAK4 | ENSPPYP00000023353 | ENSPPYP00000005053 | Interleukin 1 receptor associated kinase 1. | IRAK4 isoform 6. | 0.999 |
| IRAK1 | MAP3K7 | ENSPPYP00000023353 | ENSPPYP00000018861 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.991 |
| IRAK1 | MYD88 | ENSPPYP00000023353 | ENSPPYP00000015673 | Interleukin 1 receptor associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK1 | NGFR | ENSPPYP00000023353 | ENSPPYP00000010010 | Interleukin 1 receptor associated kinase 1. | NGFR isoform 1. | 0.955 |
| IRAK1 | TAB2 | ENSPPYP00000023353 | ENSPPYP00000019131 | Interleukin 1 receptor associated kinase 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. | 0.997 |
| IRAK1 | TIRAP | ENSPPYP00000023353 | ENSPPYP00000004627 | Interleukin 1 receptor associated kinase 1. | TIR domain containing adaptor protein. | 0.977 |
| IRAK1 | TOLLIP | ENSPPYP00000023353 | ENSPPYP00000003370 | Interleukin 1 receptor associated kinase 1. | Toll interacting protein. | 0.974 |
| IRAK1 | TRAF6 | ENSPPYP00000023353 | ENSPPYP00000003845 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
| IRAK2 | IL1R1 | ENSPPYP00000015274 | ENSPPYP00000013505 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Interleukin 1 receptor type 1. | 0.877 |
| IRAK2 | IRAK1 | ENSPPYP00000015274 | ENSPPYP00000023353 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Interleukin 1 receptor associated kinase 1. | 0.991 |
| IRAK2 | IRAK4 | ENSPPYP00000015274 | ENSPPYP00000005053 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | IRAK4 isoform 6. | 0.995 |
