Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EMC3ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)    
Predicted Functional Partners:
EMC4
ER membrane protein complex subunit 4; May mediate anti-apoptotic activity.
   
 0.998
EMC2
ER membrane protein complex subunit 2; Belongs to the EMC2 family.
   
 0.997
EMC1
ER membrane protein complex subunit 1; Belongs to the EMC1 family.
    
 0.996
MMGT1
Membrane magnesium transporter 1; Mediates Mg(2+) transport.
   
 0.996
EMC8
ER membrane protein complex subunit 8.
   
 0.989
EMC9
EMC9 isoform 1.
   
 0.988
EMC10
EMC10 isoform 4.
    
 0.988
EMC6
ER membrane protein complex subunit 6.
   
 0.986
UBAC2
UBAC2 isoform 5.
   
 
 0.854
DERL2
Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the [...]
   
 
 0.854
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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