STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EMC3ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)    
Predicted Functional Partners:
EMC4
ER membrane protein complex subunit 4; May mediate anti-apoptotic activity.
   
 0.993
EMC2
ER membrane protein complex subunit 2; Belongs to the EMC2 family.
   
 0.992
EMC1
ER membrane protein complex subunit 1; Belongs to the EMC1 family.
    
 0.990
MMGT1
Membrane magnesium transporter 1; Mediates Mg(2+) transport.
   
 0.990
EMC6
ER membrane protein complex subunit 6.
   
 0.979
EMC8
ER membrane protein complex subunit 8.
    
 0.966
EMC9
EMC9 isoform 1.
    
 0.963
EMC10
EMC10 isoform 4.
    
 0.958
DCTN4
Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (By similarity).
    
 
 0.831
UBE2G2
Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).
    
 
 0.789
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.