| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARRB1 | ARRB2 | ENSPPYP00000004214 | ENSPPYP00000008826 | ARRB1 isoform 2. | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | 0.994 |
| ARRB1 | BRPF1 | ENSPPYP00000004214 | ENSPPYP00000015298 | ARRB1 isoform 2. | BRPF1 isoform 3. | 0.754 |
| ARRB2 | ARRB1 | ENSPPYP00000008826 | ENSPPYP00000004214 | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | ARRB1 isoform 2. | 0.994 |
| ARRB2 | BRPF1 | ENSPPYP00000008826 | ENSPPYP00000015298 | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | BRPF1 isoform 3. | 0.742 |
| BRPF1 | ARRB1 | ENSPPYP00000015298 | ENSPPYP00000004214 | BRPF1 isoform 3. | ARRB1 isoform 2. | 0.754 |
| BRPF1 | ARRB2 | ENSPPYP00000015298 | ENSPPYP00000008826 | BRPF1 isoform 3. | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | 0.742 |
| BRPF1 | BRPF3 | ENSPPYP00000015298 | ENSPPYP00000018502 | BRPF1 isoform 3. | Bromodomain and PHD finger containing 3. | 0.868 |
| BRPF1 | H3-4 | ENSPPYP00000015298 | ENSPPYP00000000136 | BRPF1 isoform 3. | Histone H3; Belongs to the histone H3 family. | 0.819 |
| BRPF1 | ING5 | ENSPPYP00000015298 | ENSPPYP00000023943 | BRPF1 isoform 3. | Inhibitor of growth protein. | 0.962 |
| BRPF1 | KAT6A | ENSPPYP00000015298 | ENSPPYP00000020800 | BRPF1 isoform 3. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.962 |
| BRPF1 | KAT6B | ENSPPYP00000015298 | ENSPPYP00000002692 | BRPF1 isoform 3. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.920 |
| BRPF1 | KAT7 | ENSPPYP00000015298 | ENSPPYP00000010014 | BRPF1 isoform 3. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.870 |
| BRPF1 | LOC100436122-8 | ENSPPYP00000015298 | ENSPPYP00000023510 | BRPF1 isoform 3. | Histone H3.1. | 0.795 |
| BRPF1 | MEAF6 | ENSPPYP00000015298 | ENSPPYP00000001769 | BRPF1 isoform 3. | MYST/Esa1 associated factor 6. | 0.961 |
| BRPF3 | BRPF1 | ENSPPYP00000018502 | ENSPPYP00000015298 | Bromodomain and PHD finger containing 3. | BRPF1 isoform 3. | 0.868 |
| BRPF3 | ING5 | ENSPPYP00000018502 | ENSPPYP00000023943 | Bromodomain and PHD finger containing 3. | Inhibitor of growth protein. | 0.979 |
| BRPF3 | KAT6A | ENSPPYP00000018502 | ENSPPYP00000020800 | Bromodomain and PHD finger containing 3. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.916 |
| BRPF3 | KAT6B | ENSPPYP00000018502 | ENSPPYP00000002692 | Bromodomain and PHD finger containing 3. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.897 |
| BRPF3 | KAT7 | ENSPPYP00000018502 | ENSPPYP00000010014 | Bromodomain and PHD finger containing 3. | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. | 0.974 |
| BRPF3 | MEAF6 | ENSPPYP00000018502 | ENSPPYP00000001769 | Bromodomain and PHD finger containing 3. | MYST/Esa1 associated factor 6. | 0.984 |
