| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP4B1 | ARHGEF3 | ENSPPYP00000001174 | ENSPPYP00000015414 | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | 0.709 |
| AP4B1 | ITGAE | ENSPPYP00000001174 | ENSPPYP00000008807 | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. | ITGAE isoform 1; Belongs to the integrin alpha chain family. | 0.602 |
| AP4B1 | ITPR3 | ENSPPYP00000001174 | ENSPPYP00000018459 | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. | ITPR3 isoform 1. | 0.482 |
| ARHGEF3 | AP4B1 | ENSPPYP00000015414 | ENSPPYP00000001174 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. | 0.709 |
| ARHGEF3 | CITED4 | ENSPPYP00000015414 | ENSPPYP00000001713 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | CITED4 isoform 1. | 0.622 |
| ARHGEF3 | GNA13 | ENSPPYP00000015414 | ENSPPYP00000009607 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | G protein subunit alpha 13. | 0.646 |
| ARHGEF3 | ITGAE | ENSPPYP00000015414 | ENSPPYP00000008807 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | ITGAE isoform 1; Belongs to the integrin alpha chain family. | 0.570 |
| ARHGEF3 | ITPR3 | ENSPPYP00000015414 | ENSPPYP00000018459 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | ITPR3 isoform 1. | 0.573 |
| ARHGEF3 | LHFPL2 | ENSPPYP00000015414 | ENSPPYP00000017419 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | LHFPL tetraspan subfamily member 2. | 0.595 |
| ARHGEF3 | MAGI1 | ENSPPYP00000015414 | ENSPPYP00000015365 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | MAGI1 isoform 5. | 0.698 |
| ARHGEF3 | RHOA | ENSPPYP00000015414 | ENSPPYP00000015522 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.732 |
| ARHGEF3 | RHOC | ENSPPYP00000015414 | ENSPPYP00000001186 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). | 0.740 |
| ARHGEF3 | RHOC-2 | ENSPPYP00000015414 | ENSPPYP00000011947 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | RHOA isoform 3. | 0.618 |
| CITED4 | ARHGEF3 | ENSPPYP00000001713 | ENSPPYP00000015414 | CITED4 isoform 1. | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | 0.622 |
| GNA13 | ARHGEF3 | ENSPPYP00000009607 | ENSPPYP00000015414 | G protein subunit alpha 13. | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | 0.646 |
| GNA13 | RHOA | ENSPPYP00000009607 | ENSPPYP00000015522 | G protein subunit alpha 13. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.838 |
| GNA13 | RHOC | ENSPPYP00000009607 | ENSPPYP00000001186 | G protein subunit alpha 13. | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). | 0.765 |
| GNA13 | RHOC-2 | ENSPPYP00000009607 | ENSPPYP00000011947 | G protein subunit alpha 13. | RHOA isoform 3. | 0.758 |
| ITGAE | AP4B1 | ENSPPYP00000008807 | ENSPPYP00000001174 | ITGAE isoform 1; Belongs to the integrin alpha chain family. | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. | 0.602 |
| ITGAE | ARHGEF3 | ENSPPYP00000008807 | ENSPPYP00000015414 | ITGAE isoform 1; Belongs to the integrin alpha chain family. | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. | 0.570 |
