| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNY | MANF | ENSPPYP00000002569 | ENSPPYP00000015479 | CCNY isoform 4; Belongs to the cyclin family. | MANF isoform 1. | 0.826 |
| CCNY | PPARGC1A | ENSPPYP00000002569 | ENSPPYP00000016357 | CCNY isoform 4; Belongs to the cyclin family. | PPARG coactivator 1 alpha. | 0.802 |
| CCNY | RTN1 | ENSPPYP00000002569 | ENSPPYP00000006666 | CCNY isoform 4; Belongs to the cyclin family. | Reticulon. | 0.711 |
| CCNY | VSNL1 | ENSPPYP00000002569 | ENSPPYP00000023634 | CCNY isoform 4; Belongs to the cyclin family. | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family. | 0.854 |
| CDNF | CRELD2 | ENSPPYP00000002442 | ENSPPYP00000013353 | Cerebral dopamine neurotrophic factor. | CRELD2 isoform 3. | 0.440 |
| CDNF | HSPA5 | ENSPPYP00000002442 | ENSPPYP00000021973 | Cerebral dopamine neurotrophic factor. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.836 |
| CDNF | MANF | ENSPPYP00000002442 | ENSPPYP00000015479 | Cerebral dopamine neurotrophic factor. | MANF isoform 1. | 0.786 |
| CDNF | SSR3 | ENSPPYP00000002442 | ENSPPYP00000015913 | Cerebral dopamine neurotrophic factor. | Translocon-associated protein subunit gamma; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. | 0.504 |
| CRELD2 | CDNF | ENSPPYP00000013353 | ENSPPYP00000002442 | CRELD2 isoform 3. | Cerebral dopamine neurotrophic factor. | 0.440 |
| CRELD2 | DNAJB11 | ENSPPYP00000013353 | ENSPPYP00000016085 | CRELD2 isoform 3. | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | 0.915 |
| CRELD2 | HSPA5 | ENSPPYP00000013353 | ENSPPYP00000021973 | CRELD2 isoform 3. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.683 |
| CRELD2 | MANF | ENSPPYP00000013353 | ENSPPYP00000015479 | CRELD2 isoform 3. | MANF isoform 1. | 0.929 |
| CRELD2 | SDF2L1 | ENSPPYP00000013353 | ENSPPYP00000012946 | CRELD2 isoform 3. | SDF2L1 isoform 1. | 0.935 |
| DNAJB11 | CRELD2 | ENSPPYP00000016085 | ENSPPYP00000013353 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | CRELD2 isoform 3. | 0.915 |
| DNAJB11 | HSPA5 | ENSPPYP00000016085 | ENSPPYP00000021973 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.994 |
| DNAJB11 | MANF | ENSPPYP00000016085 | ENSPPYP00000015479 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | MANF isoform 1. | 0.906 |
| DNAJB11 | SDF2L1 | ENSPPYP00000016085 | ENSPPYP00000012946 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | SDF2L1 isoform 1. | 0.896 |
| HSPA5 | CDNF | ENSPPYP00000021973 | ENSPPYP00000002442 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | Cerebral dopamine neurotrophic factor. | 0.836 |
| HSPA5 | CRELD2 | ENSPPYP00000021973 | ENSPPYP00000013353 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | CRELD2 isoform 3. | 0.683 |
| HSPA5 | DNAJB11 | ENSPPYP00000021973 | ENSPPYP00000016085 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | 0.994 |
