CISH protein (Pongo abelii) - STRING interaction network

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second shell of interactors

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Predicted Interactions

gene neighborhood

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textmining

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Score

CISH

Cytokine inducible SH2 containing protein. (258 aa)

Predicted Functional Partners:

CUL5

0.975

STAT5B

0.971

STAT3

0.969

STAT5A

0.969

STAT1

0.967

STAT6

0.952

PRLR

0.944

RNF7

0.892

ELOC

0.867

ENSPPYP00000023677

0.867

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	CUL5	ENSPPYP00000015482	ENSPPYP00000004398	Cytokine inducible SH2 containing protein.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.975
CISH	ELOC	ENSPPYP00000015482	ENSPPYP00000020952	Cytokine inducible SH2 containing protein.	ELOC isoform 10; Belongs to the SKP1 family.	0.867
CISH	ENSPPYP00000023677	ENSPPYP00000015482	ENSPPYP00000023677	Cytokine inducible SH2 containing protein.	annotation not available	0.867
CISH	PRLR	ENSPPYP00000015482	ENSPPYP00000017194	Cytokine inducible SH2 containing protein.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.944
CISH	RNF7	ENSPPYP00000015482	ENSPPYP00000015846	Cytokine inducible SH2 containing protein.	Ring finger protein 7.	0.892
CISH	STAT1	ENSPPYP00000015482	ENSPPYP00000014555	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.967
CISH	STAT3	ENSPPYP00000015482	ENSPPYP00000009437	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.969
CISH	STAT5A	ENSPPYP00000015482	ENSPPYP00000009439	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.969
CISH	STAT5B	ENSPPYP00000015482	ENSPPYP00000009440	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.971
CISH	STAT6	ENSPPYP00000015482	ENSPPYP00000005333	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.952
CUL5	CISH	ENSPPYP00000004398	ENSPPYP00000015482	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Cytokine inducible SH2 containing protein.	0.975
CUL5	ELOC	ENSPPYP00000004398	ENSPPYP00000020952	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOC isoform 10; Belongs to the SKP1 family.	0.995
CUL5	ENSPPYP00000023677	ENSPPYP00000004398	ENSPPYP00000023677	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	annotation not available	0.983
CUL5	RNF7	ENSPPYP00000004398	ENSPPYP00000015846	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Ring finger protein 7.	0.999
ELOC	CISH	ENSPPYP00000020952	ENSPPYP00000015482	ELOC isoform 10; Belongs to the SKP1 family.	Cytokine inducible SH2 containing protein.	0.867
ELOC	CUL5	ENSPPYP00000020952	ENSPPYP00000004398	ELOC isoform 10; Belongs to the SKP1 family.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.995
ELOC	RNF7	ENSPPYP00000020952	ENSPPYP00000015846	ELOC isoform 10; Belongs to the SKP1 family.	Ring finger protein 7.	0.984
ENSPPYP00000023677	CISH	ENSPPYP00000023677	ENSPPYP00000015482	annotation not available	Cytokine inducible SH2 containing protein.	0.867
ENSPPYP00000023677	CUL5	ENSPPYP00000023677	ENSPPYP00000004398	annotation not available	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.983
ENSPPYP00000023677	RNF7	ENSPPYP00000023677	ENSPPYP00000015846	annotation not available	Ring finger protein 7.	0.926