CISH protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	CUL5	ENSPPYP00000015482	ENSPPYP00000004398	Cytokine inducible SH2 containing protein.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.956
CISH	ELOB	ENSPPYP00000015482	ENSPPYP00000007934	Cytokine inducible SH2 containing protein.	ELOB isoform 1.	0.886
CISH	ENSPPYP00000004644	ENSPPYP00000015482	ENSPPYP00000004644	Cytokine inducible SH2 containing protein.	annotation not available	0.886
CISH	PRLR	ENSPPYP00000015482	ENSPPYP00000017194	Cytokine inducible SH2 containing protein.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.916
CISH	STAT1	ENSPPYP00000015482	ENSPPYP00000014555	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.965
CISH	STAT3	ENSPPYP00000015482	ENSPPYP00000009437	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.966
CISH	STAT4	ENSPPYP00000015482	ENSPPYP00000014556	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.950
CISH	STAT5A	ENSPPYP00000015482	ENSPPYP00000009439	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.971
CISH	STAT5B	ENSPPYP00000015482	ENSPPYP00000009440	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.968
CISH	STAT6	ENSPPYP00000015482	ENSPPYP00000005333	Cytokine inducible SH2 containing protein.	Signal transducer and activator of transcription.	0.956
CUL5	CISH	ENSPPYP00000004398	ENSPPYP00000015482	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	Cytokine inducible SH2 containing protein.	0.956
CUL5	ELOB	ENSPPYP00000004398	ENSPPYP00000007934	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	ELOB isoform 1.	0.996
CUL5	ENSPPYP00000004644	ENSPPYP00000004398	ENSPPYP00000004644	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	annotation not available	0.992
ELOB	CISH	ENSPPYP00000007934	ENSPPYP00000015482	ELOB isoform 1.	Cytokine inducible SH2 containing protein.	0.886
ELOB	CUL5	ENSPPYP00000007934	ENSPPYP00000004398	ELOB isoform 1.	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.996
ELOB	ENSPPYP00000004644	ENSPPYP00000007934	ENSPPYP00000004644	ELOB isoform 1.	annotation not available	0.900
ENSPPYP00000004644	CISH	ENSPPYP00000004644	ENSPPYP00000015482	annotation not available	Cytokine inducible SH2 containing protein.	0.886
ENSPPYP00000004644	CUL5	ENSPPYP00000004644	ENSPPYP00000004398	annotation not available	Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...]	0.992
ENSPPYP00000004644	ELOB	ENSPPYP00000004644	ENSPPYP00000007934	annotation not available	ELOB isoform 1.	0.900
PRLR	CISH	ENSPPYP00000017194	ENSPPYP00000015482	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	Cytokine inducible SH2 containing protein.	0.916