| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCND1 | HRAS | ENSPPYP00000003434 | ENSPPYP00000003333 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | HRas proto-oncogene, GTPase. | 0.489 |
| CCND1 | KRAS | ENSPPYP00000003434 | ENSPPYP00000004987 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | KRAS proto-oncogene, GTPase. | 0.487 |
| CCND1 | RASSF1 | ENSPPYP00000003434 | ENSPPYP00000015490 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | RASSF1 isoform 4. | 0.947 |
| HRAS | CCND1 | ENSPPYP00000003333 | ENSPPYP00000003434 | HRas proto-oncogene, GTPase. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.489 |
| HRAS | KRAS | ENSPPYP00000003333 | ENSPPYP00000004987 | HRas proto-oncogene, GTPase. | KRAS proto-oncogene, GTPase. | 0.997 |
| HRAS | NRAS | ENSPPYP00000003333 | ENSPPYP00000001163 | HRas proto-oncogene, GTPase. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.997 |
| HRAS | RASSF1 | ENSPPYP00000003333 | ENSPPYP00000015490 | HRas proto-oncogene, GTPase. | RASSF1 isoform 4. | 0.982 |
| HRAS | TIAM1 | ENSPPYP00000003333 | ENSPPYP00000012673 | HRas proto-oncogene, GTPase. | TIAM1 isoform 1. | 0.931 |
| KRAS | CCND1 | ENSPPYP00000004987 | ENSPPYP00000003434 | KRAS proto-oncogene, GTPase. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.487 |
| KRAS | HRAS | ENSPPYP00000004987 | ENSPPYP00000003333 | KRAS proto-oncogene, GTPase. | HRas proto-oncogene, GTPase. | 0.997 |
| KRAS | NRAS | ENSPPYP00000004987 | ENSPPYP00000001163 | KRAS proto-oncogene, GTPase. | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.997 |
| KRAS | RASSF1 | ENSPPYP00000004987 | ENSPPYP00000015490 | KRAS proto-oncogene, GTPase. | RASSF1 isoform 4. | 0.973 |
| KRAS | TIAM1 | ENSPPYP00000004987 | ENSPPYP00000012673 | KRAS proto-oncogene, GTPase. | TIAM1 isoform 1. | 0.925 |
| MRAS | RASSF1 | ENSPPYP00000015821 | ENSPPYP00000015490 | Muscle RAS oncogene homolog. | RASSF1 isoform 4. | 0.912 |
| MRAS | TIAM1 | ENSPPYP00000015821 | ENSPPYP00000012673 | Muscle RAS oncogene homolog. | TIAM1 isoform 1. | 0.919 |
| NRAS | HRAS | ENSPPYP00000001163 | ENSPPYP00000003333 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | HRas proto-oncogene, GTPase. | 0.997 |
| NRAS | KRAS | ENSPPYP00000001163 | ENSPPYP00000004987 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | KRAS proto-oncogene, GTPase. | 0.997 |
| NRAS | RASSF1 | ENSPPYP00000001163 | ENSPPYP00000015490 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | RASSF1 isoform 4. | 0.946 |
| NRAS | TIAM1 | ENSPPYP00000001163 | ENSPPYP00000012673 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | TIAM1 isoform 1. | 0.924 |
| RASSF1 | CCND1 | ENSPPYP00000015490 | ENSPPYP00000003434 | RASSF1 isoform 4. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.947 |
