| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMT | ATIC | ENSPPYP00000015519 | ENSPPYP00000014690 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | 0.958 |
| AMT | DLD | ENSPPYP00000015519 | ENSPPYP00000020072 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] | 0.997 |
| AMT | GART | ENSPPYP00000015519 | ENSPPYP00000012701 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.972 |
| AMT | GCSH | ENSPPYP00000015519 | ENSPPYP00000008560 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.999 |
| AMT | GLDC | ENSPPYP00000015519 | ENSPPYP00000021533 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| AMT | MTHFD2L | ENSPPYP00000015519 | ENSPPYP00000016565 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | MTHFD2L isoform 10. | 0.979 |
| AMT | MTHFR | ENSPPYP00000015519 | ENSPPYP00000002178 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.971 |
| AMT | SHMT1 | ENSPPYP00000015519 | ENSPPYP00000009057 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.974 |
| AMT | SHMT2 | ENSPPYP00000015519 | ENSPPYP00000005336 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.974 |
| AMT | TYMS | ENSPPYP00000015519 | ENSPPYP00000010155 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | Thymidylate synthetase. | 0.960 |
| ATIC | AMT | ENSPPYP00000014690 | ENSPPYP00000015519 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. | 0.958 |
| ATIC | DLD | ENSPPYP00000014690 | ENSPPYP00000020072 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...] | 0.497 |
| ATIC | GART | ENSPPYP00000014690 | ENSPPYP00000012701 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. | 0.999 |
| ATIC | GCSH | ENSPPYP00000014690 | ENSPPYP00000008560 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.542 |
| ATIC | GLDC | ENSPPYP00000014690 | ENSPPYP00000021533 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.655 |
| ATIC | MTHFD2L | ENSPPYP00000014690 | ENSPPYP00000016565 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | MTHFD2L isoform 10. | 0.961 |
| ATIC | MTHFR | ENSPPYP00000014690 | ENSPPYP00000002178 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.549 |
| ATIC | SHMT1 | ENSPPYP00000014690 | ENSPPYP00000009057 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. | 0.978 |
| ATIC | SHMT2 | ENSPPYP00000014690 | ENSPPYP00000005336 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.978 |
| ATIC | TYMS | ENSPPYP00000014690 | ENSPPYP00000010155 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family. | Thymidylate synthetase. | 0.571 |
