NME6 protein (Pongo abelii) - STRING interaction network

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Score

NME6

Nucleoside diphosphate kinase. (194 aa)

Predicted Functional Partners:

ITPA

0.957

RRM1

0.949

HDDC3

0.949

NTPCR

0.948

DTYMK

0.946

AK9

0.938

CTPS1

0.937

CTPS2

0.937

DUT

0.935

CMPK1

0.932

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK9	CMPK1	ENSPPYP00000018934	ENSPPYP00000001599	AK9 isoform 2.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.926
AK9	CTPS1	ENSPPYP00000018934	ENSPPYP00000001712	AK9 isoform 2.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.936
AK9	CTPS2	ENSPPYP00000018934	ENSPPYP00000022544	AK9 isoform 2.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.936
AK9	DTYMK	ENSPPYP00000018934	ENSPPYP00000014942	AK9 isoform 2.	DTYMK isoform 1.	0.951
AK9	DUT	ENSPPYP00000018934	ENSPPYP00000007314	AK9 isoform 2.	Deoxyuridine triphosphatase.	0.940
AK9	HDDC3	ENSPPYP00000018934	ENSPPYP00000007700	AK9 isoform 2.	HD domain containing 3.	0.936
AK9	ITPA	ENSPPYP00000018934	ENSPPYP00000012088	AK9 isoform 2.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.929
AK9	NME6	ENSPPYP00000018934	ENSPPYP00000015557	AK9 isoform 2.	Nucleoside diphosphate kinase.	0.938
AK9	NTPCR	ENSPPYP00000018934	ENSPPYP00000000108	AK9 isoform 2.	Nucleoside-triphosphatase, cancer-related.	0.912
AK9	RRM1	ENSPPYP00000018934	ENSPPYP00000004146	AK9 isoform 2.	Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).	0.992
CMPK1	AK9	ENSPPYP00000001599	ENSPPYP00000018934	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	AK9 isoform 2.	0.926
CMPK1	CTPS1	ENSPPYP00000001599	ENSPPYP00000001712	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.541
CMPK1	CTPS2	ENSPPYP00000001599	ENSPPYP00000022544	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.483
CMPK1	DTYMK	ENSPPYP00000001599	ENSPPYP00000014942	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	DTYMK isoform 1.	0.767
CMPK1	DUT	ENSPPYP00000001599	ENSPPYP00000007314	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Deoxyuridine triphosphatase.	0.933
CMPK1	NME6	ENSPPYP00000001599	ENSPPYP00000015557	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Nucleoside diphosphate kinase.	0.932
CMPK1	RRM1	ENSPPYP00000001599	ENSPPYP00000004146	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).	0.947
CTPS1	AK9	ENSPPYP00000001712	ENSPPYP00000018934	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	AK9 isoform 2.	0.936
CTPS1	CMPK1	ENSPPYP00000001712	ENSPPYP00000001599	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.541
CTPS1	CTPS2	ENSPPYP00000001712	ENSPPYP00000022544	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.985