XCR1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCL5	ENSPPYP00000009183	ENSPPYP00000009214	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine.	0.898
CCL2	CCL8	ENSPPYP00000009183	ENSPPYP00000009184	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine.	0.988
CCL2	CXCL12	ENSPPYP00000009183	ENSPPYP00000002594	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family.	0.611
CCL2	LOC100439532	ENSPPYP00000009183	ENSPPYP00000009221	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine.	0.723
CCL2	LOC100439906	ENSPPYP00000009183	ENSPPYP00000009222	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine 4 isoform X4.	0.900
CCL2	XCR1	ENSPPYP00000009183	ENSPPYP00000015590	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.738
CCL5	CCL2	ENSPPYP00000009214	ENSPPYP00000009183	C-C motif chemokine.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.898
CCL5	CCL8	ENSPPYP00000009214	ENSPPYP00000009184	C-C motif chemokine.	C-C motif chemokine.	0.940
CCL5	CXCL12	ENSPPYP00000009214	ENSPPYP00000002594	C-C motif chemokine.	CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family.	0.972
CCL5	LOC100439906	ENSPPYP00000009214	ENSPPYP00000009222	C-C motif chemokine.	C-C motif chemokine 4 isoform X4.	0.469
CCL5	XCL1	ENSPPYP00000009214	ENSPPYP00000000629	C-C motif chemokine.	XCL2 isoform 1.	0.823
CCL5	XCL1-2	ENSPPYP00000009214	ENSPPYP00000000628	C-C motif chemokine.	XCL1 isoform 1.	0.823
CCL5	XCR1	ENSPPYP00000009214	ENSPPYP00000015590	C-C motif chemokine.	X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.743
CCL8	CCL2	ENSPPYP00000009184	ENSPPYP00000009183	C-C motif chemokine.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.988
CCL8	CCL5	ENSPPYP00000009184	ENSPPYP00000009214	C-C motif chemokine.	C-C motif chemokine.	0.940
CCL8	CXCL12	ENSPPYP00000009184	ENSPPYP00000002594	C-C motif chemokine.	CXCL12 isoform 2; Belongs to the intercrine alpha (chemokine CxC) family.	0.815
CCL8	LOC100439906	ENSPPYP00000009184	ENSPPYP00000009222	C-C motif chemokine.	C-C motif chemokine 4 isoform X4.	0.529
CCL8	XCL1	ENSPPYP00000009184	ENSPPYP00000000629	C-C motif chemokine.	XCL2 isoform 1.	0.768
CCL8	XCL1-2	ENSPPYP00000009184	ENSPPYP00000000628	C-C motif chemokine.	XCL1 isoform 1.	0.768
CCL8	XCR1	ENSPPYP00000009184	ENSPPYP00000015590	C-C motif chemokine.	X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.819