Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CTNNB1CTNNB1 isoform 2. (781 aa)    
Predicted Functional Partners:
CDH5
CDH5 isoform 2; Cadherins are calcium-dependent cell adhesion proteins.
    
 0.999
LEF1
Lymphoid enhancer binding factor 1.
    
 0.999
APC
Adenomatous polyposis coli protein isoform X2.
   
 0.999
CTNNA3
CTNNA3 isoform 1.
   
 0.998
BTRC
BTRC isoform 2.
   
 0.998
CR201_G0012836
TCF7L2 isoform 2.
    
 0.998
CHD8
Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]
   
 0.998
AXIN2
AXIN2 isoform 1.
    
 0.998
GSK3B
GSK3B isoform 2; Belongs to the protein kinase superfamily.
    
 0.998
CTNNA1
CTNNA1 isoform 1.
   
 0.998
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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