| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IRAK1 | IRAK2 | ENSPPYP00000023353 | ENSPPYP00000015274 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | 0.991 |
| IRAK1 | IRAK4 | ENSPPYP00000023353 | ENSPPYP00000005053 | Interleukin 1 receptor associated kinase 1. | IRAK4 isoform 6. | 0.999 |
| IRAK1 | MAP3K7 | ENSPPYP00000023353 | ENSPPYP00000018861 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.991 |
| IRAK1 | MYD88 | ENSPPYP00000023353 | ENSPPYP00000015673 | Interleukin 1 receptor associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.999 |
| IRAK1 | TIRAP | ENSPPYP00000023353 | ENSPPYP00000004627 | Interleukin 1 receptor associated kinase 1. | TIR domain containing adaptor protein. | 0.977 |
| IRAK1 | TLR1 | ENSPPYP00000023353 | ENSPPYP00000016387 | Interleukin 1 receptor associated kinase 1. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.590 |
| IRAK1 | TLR2 | ENSPPYP00000023353 | ENSPPYP00000016910 | Interleukin 1 receptor associated kinase 1. | Toll-like receptor. | 0.694 |
| IRAK1 | TLR4 | ENSPPYP00000023353 | ENSPPYP00000021908 | Interleukin 1 receptor associated kinase 1. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.777 |
| IRAK1 | TLR8 | ENSPPYP00000023353 | ENSPPYP00000022512 | Interleukin 1 receptor associated kinase 1. | TLR8 isoform 1; Belongs to the Toll-like receptor family. | 0.969 |
| IRAK1 | TRAF6 | ENSPPYP00000023353 | ENSPPYP00000003845 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
| IRAK2 | IRAK1 | ENSPPYP00000015274 | ENSPPYP00000023353 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Interleukin 1 receptor associated kinase 1. | 0.991 |
| IRAK2 | IRAK4 | ENSPPYP00000015274 | ENSPPYP00000005053 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | IRAK4 isoform 6. | 0.995 |
| IRAK2 | MAP3K7 | ENSPPYP00000015274 | ENSPPYP00000018861 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.863 |
| IRAK2 | MYD88 | ENSPPYP00000015274 | ENSPPYP00000015673 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. | 0.994 |
| IRAK2 | TIRAP | ENSPPYP00000015274 | ENSPPYP00000004627 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | TIR domain containing adaptor protein. | 0.870 |
| IRAK2 | TLR2 | ENSPPYP00000015274 | ENSPPYP00000016910 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | Toll-like receptor. | 0.568 |
| IRAK2 | TLR4 | ENSPPYP00000015274 | ENSPPYP00000021908 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | TLR4 isoform 1; Belongs to the Toll-like receptor family. | 0.713 |
| IRAK2 | TLR8 | ENSPPYP00000015274 | ENSPPYP00000022512 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | TLR8 isoform 1; Belongs to the Toll-like receptor family. | 0.598 |
| IRAK2 | TRAF6 | ENSPPYP00000015274 | ENSPPYP00000003845 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
| IRAK4 | IRAK1 | ENSPPYP00000005053 | ENSPPYP00000023353 | IRAK4 isoform 6. | Interleukin 1 receptor associated kinase 1. | 0.999 |
