CMTM6 protein (Pongo abelii) - STRING interaction network

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CMTM6

CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...] (183 aa)

Predicted Functional Partners:

DNAH1

0.891

INVS

0.859

CMTM8

0.740

CD151

0.736

CMTM7

0.730

CKLF

0.728

NELFCD

0.687

CR201_G0015676

0.684

CMTM4

0.677

CR201_G0032687

0.568

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD151	CMTM6	ENSPPYP00000003360	ENSPPYP00000015709	Tetraspanin.	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	0.736
CD151	CR201_G0015676	ENSPPYP00000003360	ENSPPYP00000001781	Tetraspanin.	THRAP3 isoform 1.	0.473
CD151	DNAH1	ENSPPYP00000003360	ENSPPYP00000015453	Tetraspanin.	DNAH1 isoform 1.	0.765
CD151	INVS	ENSPPYP00000003360	ENSPPYP00000021789	Tetraspanin.	INVS isoform 2.	0.767
CKLF	CMTM4	ENSPPYP00000008385	ENSPPYP00000008389	Chemokine like factor.	CMTM4 isoform 1.	0.731
CKLF	CMTM6	ENSPPYP00000008385	ENSPPYP00000015709	Chemokine like factor.	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	0.728
CKLF	CMTM7	ENSPPYP00000008385	ENSPPYP00000015710	Chemokine like factor.	CKLF like MARVEL transmembrane domain containing 7.	0.730
CKLF	CMTM8	ENSPPYP00000008385	ENSPPYP00000015711	Chemokine like factor.	CKLF like MARVEL transmembrane domain containing 8.	0.718
CKLF	CR201_G0032687	ENSPPYP00000008385	ENSPPYP00000006445	Chemokine like factor.	CMTM5 isoform 3.	0.728
CMTM4	CKLF	ENSPPYP00000008389	ENSPPYP00000008385	CMTM4 isoform 1.	Chemokine like factor.	0.731
CMTM4	CMTM6	ENSPPYP00000008389	ENSPPYP00000015709	CMTM4 isoform 1.	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	0.677
CMTM4	CMTM7	ENSPPYP00000008389	ENSPPYP00000015710	CMTM4 isoform 1.	CKLF like MARVEL transmembrane domain containing 7.	0.579
CMTM4	CMTM8	ENSPPYP00000008389	ENSPPYP00000015711	CMTM4 isoform 1.	CKLF like MARVEL transmembrane domain containing 8.	0.531
CMTM4	CR201_G0032687	ENSPPYP00000008389	ENSPPYP00000006445	CMTM4 isoform 1.	CMTM5 isoform 3.	0.582
CMTM6	CD151	ENSPPYP00000015709	ENSPPYP00000003360	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	Tetraspanin.	0.736
CMTM6	CKLF	ENSPPYP00000015709	ENSPPYP00000008385	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	Chemokine like factor.	0.728
CMTM6	CMTM4	ENSPPYP00000015709	ENSPPYP00000008389	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	CMTM4 isoform 1.	0.677
CMTM6	CMTM7	ENSPPYP00000015709	ENSPPYP00000015710	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	CKLF like MARVEL transmembrane domain containing 7.	0.730
CMTM6	CMTM8	ENSPPYP00000015709	ENSPPYP00000015711	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	CKLF like MARVEL transmembrane domain containing 8.	0.740
CMTM6	CR201_G0015676	ENSPPYP00000015709	ENSPPYP00000001781	CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]	THRAP3 isoform 1.	0.684

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