NR1D2 protein (Pongo abelii) - STRING interaction network

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Predicted Interactions

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Score

NR1D2

NR1D2 isoform 1. (504 aa)

Predicted Functional Partners:

NCOR1

0.949

ENSPPYP00000012589

0.949

PER2

0.814

PER3

0.806

CLOCK

0.780

NCOR2

0.779

NPAS2

0.770

MED1

0.765

CRY1

0.752

NFIL3

0.750

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLOCK	CRY1	ENSPPYP00000016487	ENSPPYP00000005604	Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...]	Cryptochrome circadian regulator 1.	0.996
CLOCK	NFIL3	ENSPPYP00000016487	ENSPPYP00000021703	Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...]	Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]	0.704
CLOCK	NPAS2	ENSPPYP00000016487	ENSPPYP00000013492	Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...]	NPAS2 isoform 1.	0.992
CLOCK	NR1D2	ENSPPYP00000016487	ENSPPYP00000015735	Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...]	NR1D2 isoform 1.	0.780
CLOCK	PER2	ENSPPYP00000016487	ENSPPYP00000014901	Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...]	PER2 isoform 2.	0.986
CLOCK	PER3	ENSPPYP00000016487	ENSPPYP00000002238	Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...]	PER3 isoform 5.	0.785
CRY1	CLOCK	ENSPPYP00000005604	ENSPPYP00000016487	Cryptochrome circadian regulator 1.	Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, [...]	0.996
CRY1	NFIL3	ENSPPYP00000005604	ENSPPYP00000021703	Cryptochrome circadian regulator 1.	Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]	0.707
CRY1	NPAS2	ENSPPYP00000005604	ENSPPYP00000013492	Cryptochrome circadian regulator 1.	NPAS2 isoform 1.	0.994
CRY1	NR1D2	ENSPPYP00000005604	ENSPPYP00000015735	Cryptochrome circadian regulator 1.	NR1D2 isoform 1.	0.752
CRY1	PER2	ENSPPYP00000005604	ENSPPYP00000014901	Cryptochrome circadian regulator 1.	PER2 isoform 2.	0.999
CRY1	PER3	ENSPPYP00000005604	ENSPPYP00000002238	Cryptochrome circadian regulator 1.	PER3 isoform 5.	0.988
ENSPPYP00000012589	MED1	ENSPPYP00000012589	ENSPPYP00000009539	Putative nuclear receptor corepressor 1-like protein NCOR1P1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	0.602
ENSPPYP00000012589	NCOR2	ENSPPYP00000012589	ENSPPYP00000005808	Putative nuclear receptor corepressor 1-like protein NCOR1P1.	NCOR2 isoform 6.	0.913
ENSPPYP00000012589	NR1D2	ENSPPYP00000012589	ENSPPYP00000015735	Putative nuclear receptor corepressor 1-like protein NCOR1P1.	NR1D2 isoform 1.	0.949
MED1	ENSPPYP00000012589	ENSPPYP00000009539	ENSPPYP00000012589	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	Putative nuclear receptor corepressor 1-like protein NCOR1P1.	0.602
MED1	NCOR1	ENSPPYP00000009539	ENSPPYP00000009011	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	NCOR1 isoform 1.	0.602
MED1	NCOR2	ENSPPYP00000009539	ENSPPYP00000005808	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	NCOR2 isoform 6.	0.654
MED1	NR1D2	ENSPPYP00000009539	ENSPPYP00000015735	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	NR1D2 isoform 1.	0.765
NCOR1	MED1	ENSPPYP00000009011	ENSPPYP00000009539	NCOR1 isoform 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for [...]	0.602