UBA5 protein (Pongo abelii) - STRING interaction network

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOLL	CDC20B	ENSPPYP00000014582	ENSPPYP00000017282	BOLL isoform 2.	CDC20B isoform 4.	0.924
BOLL	UBA5	ENSPPYP00000014582	ENSPPYP00000015785	BOLL isoform 2.	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	0.915
CDC20B	BOLL	ENSPPYP00000017282	ENSPPYP00000014582	CDC20B isoform 4.	BOLL isoform 2.	0.924
CDC20B	UBA5	ENSPPYP00000017282	ENSPPYP00000015785	CDC20B isoform 4.	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	0.856
GABARAPL2	UBA3	ENSPPYP00000008538	ENSPPYP00000015351	GABA type A receptor associated protein like 2.	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	0.558
GABARAPL2	UBA5	ENSPPYP00000008538	ENSPPYP00000015785	GABA type A receptor associated protein like 2.	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	0.929
GABARAPL2	UFM1	ENSPPYP00000008538	ENSPPYP00000006031	GABA type A receptor associated protein like 2.	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1- ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription. Other substrates may include DDRGK1 with which it may play [...]	0.425
SEC63	UBA5	ENSPPYP00000018910	ENSPPYP00000015785	Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane [...]	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	0.904
SEC63	UFL1	ENSPPYP00000018910	ENSPPYP00000018866	Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane [...]	UFL1 isoform 2.	0.490
UBA3	GABARAPL2	ENSPPYP00000015351	ENSPPYP00000008538	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	GABA type A receptor associated protein like 2.	0.558
UBA3	UBA5	ENSPPYP00000015351	ENSPPYP00000015785	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	0.830
UBA3	UBE2H	ENSPPYP00000015351	ENSPPYP00000020192	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family.	0.922
UBA3	UBE2J2	ENSPPYP00000015351	ENSPPYP00000002333	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	Ubiquitin conjugating enzyme E2 J2.	0.826
UBA3	UFC1	ENSPPYP00000015351	ENSPPYP00000000712	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.	0.402
UBA3	UFL1	ENSPPYP00000015351	ENSPPYP00000018866	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	UFL1 isoform 2.	0.490
UBA3	UFM1	ENSPPYP00000015351	ENSPPYP00000006031	NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity).	Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1- ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription. Other substrates may include DDRGK1 with which it may play [...]	0.594
UBA5	BOLL	ENSPPYP00000015785	ENSPPYP00000014582	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	BOLL isoform 2.	0.915
UBA5	CDC20B	ENSPPYP00000015785	ENSPPYP00000017282	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	CDC20B isoform 4.	0.856
UBA5	GABARAPL2	ENSPPYP00000015785	ENSPPYP00000008538	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	GABA type A receptor associated protein like 2.	0.929
UBA5	SEC63	ENSPPYP00000015785	ENSPPYP00000018910	Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2.	Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane [...]	0.904