STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NCK1Cytoplasmic protein. (377 aa)    
Predicted Functional Partners:
LCP2
LCP2 isoform 3.
    
 0.999
PAK1
Non-specific serine/threonine protein kinase.
    
 0.996
NCK2
Cytoplasmic protein.
  
 
0.983
WASL
WASL isoform 1.
    
 0.981
VAV1
VAV1 isoform 2.
    
0.980
WIPF1
WAS/WASL interacting protein family member 1.
    
 0.978
WAS
WAS isoform 1.
    
 0.976
PAK3
Non-specific serine/threonine protein kinase.
    
 0.967
PAK2
Non-specific serine/threonine protein kinase.
    
 0.964
PAK6
Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase fam [...]
    
 0.961
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.