DBR1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG4A	DBR1	ENSPPYP00000023081	ENSPPYP00000015817	Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity).	Debranching RNA lariats 1.	0.621
CR201_G0031943	DBR1	ENSPPYP00000011950	ENSPPYP00000015817	POLR3H isoform 1.	Debranching RNA lariats 1.	0.510
CR201_G0031943	ENSPPYP00000007805	ENSPPYP00000011950	ENSPPYP00000007805	POLR3H isoform 1.	annotation not available	0.923
CR201_G0031943	NUDT21	ENSPPYP00000011950	ENSPPYP00000008319	POLR3H isoform 1.	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	0.509
CWF19L1	DBR1	ENSPPYP00000002977	ENSPPYP00000015817	CWF19-like protein 1; Belongs to the CWF19 family.	Debranching RNA lariats 1.	0.737
DBR1	ATG4A	ENSPPYP00000015817	ENSPPYP00000023081	Debranching RNA lariats 1.	Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity).	0.621
DBR1	CR201_G0031943	ENSPPYP00000015817	ENSPPYP00000011950	Debranching RNA lariats 1.	POLR3H isoform 1.	0.510
DBR1	CWF19L1	ENSPPYP00000015817	ENSPPYP00000002977	Debranching RNA lariats 1.	CWF19-like protein 1; Belongs to the CWF19 family.	0.737
DBR1	DHX38	ENSPPYP00000015817	ENSPPYP00000008486	Debranching RNA lariats 1.	DHX38 isoform 1.	0.877
DBR1	ENSPPYP00000007805	ENSPPYP00000015817	ENSPPYP00000007805	Debranching RNA lariats 1.	annotation not available	0.625
DBR1	GPATCH11	ENSPPYP00000015817	ENSPPYP00000013954	Debranching RNA lariats 1.	GPATCH11 isoform 1.	0.737
DBR1	LTN1	ENSPPYP00000015817	ENSPPYP00000012638	Debranching RNA lariats 1.	LTN1 isoform 1.	0.570
DBR1	METTL9	ENSPPYP00000015817	ENSPPYP00000023543	Debranching RNA lariats 1.	METTL9 isoform 3.	0.560
DBR1	NUDT21	ENSPPYP00000015817	ENSPPYP00000008319	Debranching RNA lariats 1.	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	0.539
DBR1	VPS13A	ENSPPYP00000015817	ENSPPYP00000021631	Debranching RNA lariats 1.	VPS13A isoform 1.	0.668
DHX38	DBR1	ENSPPYP00000008486	ENSPPYP00000015817	DHX38 isoform 1.	Debranching RNA lariats 1.	0.877
DHX38	NUDT21	ENSPPYP00000008486	ENSPPYP00000008319	DHX38 isoform 1.	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	0.686
ENSPPYP00000007805	CR201_G0031943	ENSPPYP00000007805	ENSPPYP00000011950	annotation not available	POLR3H isoform 1.	0.923
ENSPPYP00000007805	DBR1	ENSPPYP00000007805	ENSPPYP00000015817	annotation not available	Debranching RNA lariats 1.	0.625
ENSPPYP00000007805	NUDT21	ENSPPYP00000007805	ENSPPYP00000008319	annotation not available	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	0.654