Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RBP1RBP1 isoform 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)    
Predicted Functional Partners:
STRA6
Receptor for retinol uptake STRA6; Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT- dependent generation of retinol metabolites that then trigger activation of JAK2 and i [...]
     
 0.865
TTR
Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family.
   
 
 0.859
LRAT
LRAT isoform 2.
     
 0.851
RBP4
Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma.
   
 
 0.722
RDH11
Retinol dehydrogenase 11 precursor.
     
 0.686
RLBP1
RLBP1 isoform 1.
      
 0.586
RGR
RGR isoform 1; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
      
 0.532
KCNV2
KCNV2 isoform 1; Belongs to the potassium channel family.
   
  
 0.518
RBP3
Retinol binding protein 3.
      
 0.517
LYZL4
LYZL4 isoform 1; Belongs to the glycosyl hydrolase 22 family.
     
 0.514
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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