node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP10D | NCEH1 | ENSPPYP00000016433 | ENSPPYP00000015990 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.567 |
BDKRB1 | BDKRB2 | ENSPPYP00000006960 | ENSPPYP00000006959 | B1 bradykinin receptor isoform X2. | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | 0.972 |
BDKRB1 | NCEH1 | ENSPPYP00000006960 | ENSPPYP00000015990 | B1 bradykinin receptor isoform X2. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.753 |
BDKRB2 | BDKRB1 | ENSPPYP00000006959 | ENSPPYP00000006960 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | B1 bradykinin receptor isoform X2. | 0.972 |
BDKRB2 | NCEH1 | ENSPPYP00000006959 | ENSPPYP00000015990 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.707 |
C1QBP | NCEH1 | ENSPPYP00000008859 | ENSPPYP00000015990 | Complement C1q binding protein. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.625 |
CES1 | MGLL | ENSPPYP00000008315 | ENSPPYP00000015033 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Monoglyceride lipase. | 0.506 |
CES1 | NCEH1 | ENSPPYP00000008315 | ENSPPYP00000015990 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.586 |
ENSPPYP00000008314 | MGLL | ENSPPYP00000008314 | ENSPPYP00000015033 | Liver carboxylesterase 1-like isoform X1. | Monoglyceride lipase. | 0.506 |
ENSPPYP00000008314 | NCEH1 | ENSPPYP00000008314 | ENSPPYP00000015990 | Liver carboxylesterase 1-like isoform X1. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.586 |
KYNU | NCEH1 | ENSPPYP00000014317 | ENSPPYP00000015990 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.658 |
KYNU | TDO2 | ENSPPYP00000014317 | ENSPPYP00000016928 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.921 |
MGLL | CES1 | ENSPPYP00000015033 | ENSPPYP00000008315 | Monoglyceride lipase. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.506 |
MGLL | ENSPPYP00000008314 | ENSPPYP00000015033 | ENSPPYP00000008314 | Monoglyceride lipase. | Liver carboxylesterase 1-like isoform X1. | 0.506 |
MGLL | NCEH1 | ENSPPYP00000015033 | ENSPPYP00000015990 | Monoglyceride lipase. | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | 0.748 |
NCEH1 | ATP10D | ENSPPYP00000015990 | ENSPPYP00000016433 | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. | 0.567 |
NCEH1 | BDKRB1 | ENSPPYP00000015990 | ENSPPYP00000006960 | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | B1 bradykinin receptor isoform X2. | 0.753 |
NCEH1 | BDKRB2 | ENSPPYP00000015990 | ENSPPYP00000006959 | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. | 0.707 |
NCEH1 | C1QBP | ENSPPYP00000015990 | ENSPPYP00000008859 | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | Complement C1q binding protein. | 0.625 |
NCEH1 | CES1 | ENSPPYP00000015990 | ENSPPYP00000008315 | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity); Belongs to the 'GDXG' lipolytic enzyme family. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.586 |