Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)    
Predicted Functional Partners:
ADIPOR2
Adiponectin receptor 2.
    
 0.997
ADIPOR1
ADIPOR1 isoform 2.
    
 0.995
CFD
CFD isoform 1; Belongs to the peptidase S1 family.
   
  
 0.977
PLIN1
Perilipin; Belongs to the perilipin family.
   
  
 0.963
FABP4
Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
   
 
 0.912
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]
   
  
 0.857
RETN
RETN isoform 2.
   
  
 0.850
PPARG
Peroxisome proliferator-activated receptor gamma.
   
 0.796
INS-IGF2
INS isoform 4; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      
 0.741
PPARA
Peroxisome proliferator activated receptor alpha.
   
 0.714
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (14%) [HD]