IL1RAP protein (Pongo abelii) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1A	IL1B	ENSPPYP00000013572	ENSPPYP00000013573	Interleukin-1; Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.999
IL1A	IL1F10	ENSPPYP00000013572	ENSPPYP00000013579	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.529
IL1A	IL1RAP	ENSPPYP00000013572	ENSPPYP00000016112	Interleukin-1; Belongs to the IL-1 family.	IL1RAP isoform 17.	0.900
IL1A	IL1RN	ENSPPYP00000013572	ENSPPYP00000013580	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.666
IL1A	IL33	ENSPPYP00000013572	ENSPPYP00000021536	Interleukin-1; Belongs to the IL-1 family.	Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity); Belongs to the IL-1 family. Highly divergent.	0.690
IL1A	IL36A	ENSPPYP00000013572	ENSPPYP00000013576	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.495
IL1A	IL36B	ENSPPYP00000013572	ENSPPYP00000013577	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.491
IL1A	IL36G	ENSPPYP00000013572	ENSPPYP00000013575	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.510
IL1A	IL36RN	ENSPPYP00000013572	ENSPPYP00000013578	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.574
IL1A	MYD88	ENSPPYP00000013572	ENSPPYP00000015673	Interleukin-1; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.766
IL1B	IL1A	ENSPPYP00000013573	ENSPPYP00000013572	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1; Belongs to the IL-1 family.	0.999
IL1B	IL1F10	ENSPPYP00000013573	ENSPPYP00000013579	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.514
IL1B	IL1RAP	ENSPPYP00000013573	ENSPPYP00000016112	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	IL1RAP isoform 17.	0.900
IL1B	IL1RN	ENSPPYP00000013573	ENSPPYP00000013580	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.665
IL1B	IL33	ENSPPYP00000013573	ENSPPYP00000021536	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity); Belongs to the IL-1 family. Highly divergent.	0.653
IL1B	IL36A	ENSPPYP00000013573	ENSPPYP00000013576	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.492
IL1B	IL36B	ENSPPYP00000013573	ENSPPYP00000013577	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.477
IL1B	IL36G	ENSPPYP00000013573	ENSPPYP00000013575	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.557
IL1B	IL36RN	ENSPPYP00000013573	ENSPPYP00000013578	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.684
IL1B	MYD88	ENSPPYP00000013573	ENSPPYP00000015673	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.828