IL1RAP protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IL1RAP

IL1RAP isoform 17. (685 aa)

Predicted Functional Partners:

MYD88

0.914

IL1R1

0.900

IL1A

0.900

IL1B

0.900

IL36G

0.900

IL36A

0.900

IL36B

0.900

IL36RN

0.900

IL1F10

0.900

IL1RN

0.900

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1A	IL1B	ENSPPYP00000013572	ENSPPYP00000013573	Interleukin-1; Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.999
IL1A	IL1F10	ENSPPYP00000013572	ENSPPYP00000013579	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.671
IL1A	IL1R1	ENSPPYP00000013572	ENSPPYP00000013505	Interleukin-1; Belongs to the IL-1 family.	Interleukin 1 receptor type 1.	0.998
IL1A	IL1RAP	ENSPPYP00000013572	ENSPPYP00000016112	Interleukin-1; Belongs to the IL-1 family.	IL1RAP isoform 17.	0.900
IL1A	IL1RN	ENSPPYP00000013572	ENSPPYP00000013580	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.833
IL1A	IL36A	ENSPPYP00000013572	ENSPPYP00000013576	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.587
IL1A	IL36G	ENSPPYP00000013572	ENSPPYP00000013575	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.563
IL1A	IL36RN	ENSPPYP00000013572	ENSPPYP00000013578	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.633
IL1A	MYD88	ENSPPYP00000013572	ENSPPYP00000015673	Interleukin-1; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.925
IL1B	IL1A	ENSPPYP00000013573	ENSPPYP00000013572	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1; Belongs to the IL-1 family.	0.999
IL1B	IL1F10	ENSPPYP00000013573	ENSPPYP00000013579	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.597
IL1B	IL1R1	ENSPPYP00000013573	ENSPPYP00000013505	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 1 receptor type 1.	0.999
IL1B	IL1RAP	ENSPPYP00000013573	ENSPPYP00000016112	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	IL1RAP isoform 17.	0.900
IL1B	IL1RN	ENSPPYP00000013573	ENSPPYP00000013580	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.786
IL1B	IL36G	ENSPPYP00000013573	ENSPPYP00000013575	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.673
IL1B	IL36RN	ENSPPYP00000013573	ENSPPYP00000013578	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.730
IL1B	MYD88	ENSPPYP00000013573	ENSPPYP00000015673	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.943
IL1F10	IL1A	ENSPPYP00000013579	ENSPPYP00000013572	Interleukin-1.	Interleukin-1; Belongs to the IL-1 family.	0.671
IL1F10	IL1B	ENSPPYP00000013579	ENSPPYP00000013573	Interleukin-1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.597
IL1F10	IL1R1	ENSPPYP00000013579	ENSPPYP00000013505	Interleukin-1.	Interleukin 1 receptor type 1.	0.855