node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SGF29 | SUPT20H | ENSPPYP00000008178 | ENSPPYP00000006026 | SAGA complex associated factor 29. | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | 0.994 |
SGF29 | SUPT3H | ENSPPYP00000008178 | ENSPPYP00000018640 | SAGA complex associated factor 29. | SPT3 homolog, SAGA and STAGA complex component. | 0.992 |
SGF29 | SUPT7L | ENSPPYP00000008178 | ENSPPYP00000014002 | SAGA complex associated factor 29. | SUPT7L isoform 2. | 0.993 |
SGF29 | TADA2B | ENSPPYP00000008178 | ENSPPYP00000016284 | SAGA complex associated factor 29. | Transcriptional adapter 2-beta; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. | 0.997 |
SGF29 | TADA3 | ENSPPYP00000008178 | ENSPPYP00000015293 | SAGA complex associated factor 29. | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). | 0.998 |
SGF29 | TAF10 | ENSPPYP00000008178 | ENSPPYP00000004055 | SAGA complex associated factor 29. | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. | 0.993 |
SGF29 | TAF12 | ENSPPYP00000008178 | ENSPPYP00000001889 | SAGA complex associated factor 29. | TAF12 isoform 2. | 0.994 |
SGF29 | TAF5L | ENSPPYP00000008178 | ENSPPYP00000000126 | SAGA complex associated factor 29. | TAF5L isoform 1. | 0.994 |
SGF29 | TAF9B | ENSPPYP00000008178 | ENSPPYP00000022945 | SAGA complex associated factor 29. | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). | 0.962 |
SGF29 | TRRAP | ENSPPYP00000008178 | ENSPPYP00000019457 | SAGA complex associated factor 29. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.991 |
SUPT20H | SGF29 | ENSPPYP00000006026 | ENSPPYP00000008178 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | SAGA complex associated factor 29. | 0.994 |
SUPT20H | SUPT3H | ENSPPYP00000006026 | ENSPPYP00000018640 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | SPT3 homolog, SAGA and STAGA complex component. | 0.992 |
SUPT20H | SUPT7L | ENSPPYP00000006026 | ENSPPYP00000014002 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | SUPT7L isoform 2. | 0.997 |
SUPT20H | TADA2B | ENSPPYP00000006026 | ENSPPYP00000016284 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | Transcriptional adapter 2-beta; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2. | 0.994 |
SUPT20H | TADA3 | ENSPPYP00000006026 | ENSPPYP00000015293 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). | 0.995 |
SUPT20H | TAF10 | ENSPPYP00000006026 | ENSPPYP00000004055 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. | 0.996 |
SUPT20H | TAF12 | ENSPPYP00000006026 | ENSPPYP00000001889 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | TAF12 isoform 2. | 0.996 |
SUPT20H | TAF5L | ENSPPYP00000006026 | ENSPPYP00000000126 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | TAF5L isoform 1. | 0.996 |
SUPT20H | TAF9B | ENSPPYP00000006026 | ENSPPYP00000022945 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity). | 0.907 |
SUPT20H | TRRAP | ENSPPYP00000006026 | ENSPPYP00000019457 | Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy (By similarity). Belongs to the SPT20 family. | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. | 0.994 |