| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CREB1 | FOXO1 | ENSPPYP00000014658 | ENSPPYP00000006042 | CREB1 isoform 1. | FOXO1 isoform 1. | 0.524 |
| CREB1 | MAPK14 | ENSPPYP00000014658 | ENSPPYP00000018500 | CREB1 isoform 1. | Mitogen-activated protein kinase. | 0.540 |
| CREB1 | PPARG | ENSPPYP00000014658 | ENSPPYP00000015259 | CREB1 isoform 1. | Peroxisome proliferator-activated receptor gamma. | 0.447 |
| CREB1 | PPARGC1A | ENSPPYP00000014658 | ENSPPYP00000016357 | CREB1 isoform 1. | PPARG coactivator 1 alpha. | 0.971 |
| CREB1 | SIRT1 | ENSPPYP00000014658 | ENSPPYP00000002788 | CREB1 isoform 1. | SIRT1 isoform 1. | 0.565 |
| ESRRG | PPARGC1A | ENSPPYP00000000224 | ENSPPYP00000016357 | Estrogen-related receptor gamma; Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle (By similarity). | PPARG coactivator 1 alpha. | 0.963 |
| FOXO1 | CREB1 | ENSPPYP00000006042 | ENSPPYP00000014658 | FOXO1 isoform 1. | CREB1 isoform 1. | 0.524 |
| FOXO1 | MAPK14 | ENSPPYP00000006042 | ENSPPYP00000018500 | FOXO1 isoform 1. | Mitogen-activated protein kinase. | 0.940 |
| FOXO1 | PPARA | ENSPPYP00000006042 | ENSPPYP00000013328 | FOXO1 isoform 1. | Peroxisome proliferator activated receptor alpha. | 0.434 |
| FOXO1 | PPARG | ENSPPYP00000006042 | ENSPPYP00000015259 | FOXO1 isoform 1. | Peroxisome proliferator-activated receptor gamma. | 0.603 |
| FOXO1 | PPARGC1A | ENSPPYP00000006042 | ENSPPYP00000016357 | FOXO1 isoform 1. | PPARG coactivator 1 alpha. | 0.993 |
| FOXO1 | PRKAA1 | ENSPPYP00000006042 | ENSPPYP00000017227 | FOXO1 isoform 1. | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] | 0.933 |
| FOXO1 | SIRT1 | ENSPPYP00000006042 | ENSPPYP00000002788 | FOXO1 isoform 1. | SIRT1 isoform 1. | 0.997 |
| MAPK14 | CREB1 | ENSPPYP00000018500 | ENSPPYP00000014658 | Mitogen-activated protein kinase. | CREB1 isoform 1. | 0.540 |
| MAPK14 | FOXO1 | ENSPPYP00000018500 | ENSPPYP00000006042 | Mitogen-activated protein kinase. | FOXO1 isoform 1. | 0.940 |
| MAPK14 | PPARG | ENSPPYP00000018500 | ENSPPYP00000015259 | Mitogen-activated protein kinase. | Peroxisome proliferator-activated receptor gamma. | 0.463 |
| MAPK14 | PPARGC1A | ENSPPYP00000018500 | ENSPPYP00000016357 | Mitogen-activated protein kinase. | PPARG coactivator 1 alpha. | 0.965 |
| NRF1 | PPARG | ENSPPYP00000020190 | ENSPPYP00000015259 | Nuclear respiratory factor 1. | Peroxisome proliferator-activated receptor gamma. | 0.493 |
| NRF1 | PPARGC1A | ENSPPYP00000020190 | ENSPPYP00000016357 | Nuclear respiratory factor 1. | PPARG coactivator 1 alpha. | 0.985 |
| NRF1 | SIRT1 | ENSPPYP00000020190 | ENSPPYP00000002788 | Nuclear respiratory factor 1. | SIRT1 isoform 1. | 0.493 |
