STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa)    
Predicted Functional Partners:
TLR2
Toll-like receptor.
   
0.999
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.991
TLR6
Toll-like receptor.
  
0.991
LY96
Lymphocyte antigen 96.
   
 0.908
HSPA9
Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging.
    
  0.907
ENSPPYP00000024257
LOW QUALITY PROTEIN: stress-70 protein, mitochondrial-like.
    
  0.907
TLR4
TLR4 isoform 1; Belongs to the Toll-like receptor family.
   
0.867
TIRAP
TIR domain containing adaptor protein.
   
 0.862
TLR10
Toll like receptor 10; Belongs to the Toll-like receptor family.
  
 
 
0.858
CD36
CD36 isoform 15; Belongs to the CD36 family.
   
 0.798
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.