| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGDIB | RHOH | ENSPPYP00000004944 | ENSPPYP00000016404 | ARHGDIB isoform 2. | Ras homolog family member H. | 0.769 |
| FAM92B | RHOH | ENSPPYP00000008590 | ENSPPYP00000016404 | FAM92B isoform 2. | Ras homolog family member H. | 0.809 |
| FAM92B | SPINK14 | ENSPPYP00000008590 | ENSPPYP00000017812 | FAM92B isoform 2. | Serine peptidase inhibitor, Kazal type 14 (putative). | 0.875 |
| FAM92B | SPINK6 | ENSPPYP00000008590 | ENSPPYP00000017813 | FAM92B isoform 2. | Serine peptidase inhibitor, Kazal type 6. | 0.876 |
| ITSN2 | PAK2 | ENSPPYP00000014069 | ENSPPYP00000016156 | ITSN2 isoform 3. | Non-specific serine/threonine protein kinase. | 0.476 |
| ITSN2 | RHOH | ENSPPYP00000014069 | ENSPPYP00000016404 | ITSN2 isoform 3. | Ras homolog family member H. | 0.865 |
| ITSN2 | ZAP70 | ENSPPYP00000014069 | ENSPPYP00000013469 | ITSN2 isoform 3. | Tyrosine-protein kinase. | 0.425 |
| LAMTOR1 | MTR | ENSPPYP00000004168 | ENSPPYP00000000082 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.611 |
| LAMTOR1 | PAK2 | ENSPPYP00000004168 | ENSPPYP00000016156 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | Non-specific serine/threonine protein kinase. | 0.611 |
| LAMTOR1 | RHOH | ENSPPYP00000004168 | ENSPPYP00000016404 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | Ras homolog family member H. | 0.750 |
| LAMTOR1 | TMEM59 | ENSPPYP00000004168 | ENSPPYP00000001540 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. | 0.611 |
| LAMTOR1 | ZAP70 | ENSPPYP00000004168 | ENSPPYP00000013469 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | Tyrosine-protein kinase. | 0.490 |
| MTR | LAMTOR1 | ENSPPYP00000000082 | ENSPPYP00000004168 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.611 |
| MTR | PAK2 | ENSPPYP00000000082 | ENSPPYP00000016156 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Non-specific serine/threonine protein kinase. | 0.611 |
| MTR | RHOH | ENSPPYP00000000082 | ENSPPYP00000016404 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Ras homolog family member H. | 0.747 |
| MTR | TMEM59 | ENSPPYP00000000082 | ENSPPYP00000001540 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. | 0.619 |
| MTR | ZAP70 | ENSPPYP00000000082 | ENSPPYP00000013469 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Tyrosine-protein kinase. | 0.490 |
| PAK2 | ITSN2 | ENSPPYP00000016156 | ENSPPYP00000014069 | Non-specific serine/threonine protein kinase. | ITSN2 isoform 3. | 0.476 |
| PAK2 | LAMTOR1 | ENSPPYP00000016156 | ENSPPYP00000004168 | Non-specific serine/threonine protein kinase. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.611 |
| PAK2 | MTR | ENSPPYP00000016156 | ENSPPYP00000000082 | Non-specific serine/threonine protein kinase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.611 |
