MOB1B protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MOB1B

MOB kinase activator 1B. (216 aa)

Predicted Functional Partners:

MOB1A

0.994

LATS1

0.992

LATS2

0.981

STK3

0.973

STK38L

0.921

SAV1

0.862

STK38

0.855

STK4

0.809

WWTR1

0.721

YAP1

0.714

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LATS1	LATS2	ENSPPYP00000019136	ENSPPYP00000005920	Large tumor suppressor kinase 1.	Non-specific serine/threonine protein kinase.	0.991
LATS1	MOB1A	ENSPPYP00000019136	ENSPPYP00000013698	Large tumor suppressor kinase 1.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.991
LATS1	MOB1B	ENSPPYP00000019136	ENSPPYP00000016542	Large tumor suppressor kinase 1.	MOB kinase activator 1B.	0.992
LATS1	SAV1	ENSPPYP00000019136	ENSPPYP00000006597	Large tumor suppressor kinase 1.	Salvador family WW domain containing protein 1.	0.975
LATS1	STK3	ENSPPYP00000019136	ENSPPYP00000021064	Large tumor suppressor kinase 1.	STK3 isoform 3.	0.992
LATS1	STK4	ENSPPYP00000019136	ENSPPYP00000012335	Large tumor suppressor kinase 1.	STK4 isoform 1.	0.825
LATS1	WWTR1	ENSPPYP00000019136	ENSPPYP00000015879	Large tumor suppressor kinase 1.	WW domain containing transcription regulator 1.	0.996
LATS1	YAP1	ENSPPYP00000019136	ENSPPYP00000004354	Large tumor suppressor kinase 1.	YAP1 isoform 2.	0.998
LATS2	LATS1	ENSPPYP00000005920	ENSPPYP00000019136	Non-specific serine/threonine protein kinase.	Large tumor suppressor kinase 1.	0.991
LATS2	MOB1A	ENSPPYP00000005920	ENSPPYP00000013698	Non-specific serine/threonine protein kinase.	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	0.980
LATS2	MOB1B	ENSPPYP00000005920	ENSPPYP00000016542	Non-specific serine/threonine protein kinase.	MOB kinase activator 1B.	0.981
LATS2	SAV1	ENSPPYP00000005920	ENSPPYP00000006597	Non-specific serine/threonine protein kinase.	Salvador family WW domain containing protein 1.	0.976
LATS2	STK3	ENSPPYP00000005920	ENSPPYP00000021064	Non-specific serine/threonine protein kinase.	STK3 isoform 3.	0.972
LATS2	STK4	ENSPPYP00000005920	ENSPPYP00000012335	Non-specific serine/threonine protein kinase.	STK4 isoform 1.	0.898
LATS2	WWTR1	ENSPPYP00000005920	ENSPPYP00000015879	Non-specific serine/threonine protein kinase.	WW domain containing transcription regulator 1.	0.986
LATS2	YAP1	ENSPPYP00000005920	ENSPPYP00000004354	Non-specific serine/threonine protein kinase.	YAP1 isoform 2.	0.997
MOB1A	LATS1	ENSPPYP00000013698	ENSPPYP00000019136	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Large tumor suppressor kinase 1.	0.991
MOB1A	LATS2	ENSPPYP00000013698	ENSPPYP00000005920	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Non-specific serine/threonine protein kinase.	0.980
MOB1A	MOB1B	ENSPPYP00000013698	ENSPPYP00000016542	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	MOB kinase activator 1B.	0.994
MOB1A	SAV1	ENSPPYP00000013698	ENSPPYP00000006597	MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...]	Salvador family WW domain containing protein 1.	0.887