| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADA | CDA | ENSPPYP00000012327 | ENSPPYP00000002054 | Adenosine deaminase. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.545 |
| ADA | DCK | ENSPPYP00000012327 | ENSPPYP00000016543 | Adenosine deaminase. | Deoxycytidine kinase. | 0.926 |
| ADA | NT5C | ENSPPYP00000012327 | ENSPPYP00000009679 | Adenosine deaminase. | 5', 3'-nucleotidase, cytosolic. | 0.940 |
| ADA | NT5C2 | ENSPPYP00000012327 | ENSPPYP00000003045 | Adenosine deaminase. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). Belongs to the 5'(3')-deoxyribonucleotidase family. | 0.917 |
| ADA | NT5DC4 | ENSPPYP00000012327 | ENSPPYP00000013570 | Adenosine deaminase. | NT5DC4 isoform 1. | 0.916 |
| ADA | PNP | ENSPPYP00000012327 | ENSPPYP00000006336 | Adenosine deaminase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.987 |
| CDA | ADA | ENSPPYP00000002054 | ENSPPYP00000012327 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Adenosine deaminase. | 0.545 |
| CDA | CMPK1 | ENSPPYP00000002054 | ENSPPYP00000001599 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.413 |
| CDA | DCK | ENSPPYP00000002054 | ENSPPYP00000016543 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Deoxycytidine kinase. | 0.982 |
| CDA | DCTD | ENSPPYP00000002054 | ENSPPYP00000017005 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.672 |
| CDA | DGUOK | ENSPPYP00000002054 | ENSPPYP00000013701 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | DGUOK isoform 2. | 0.613 |
| CDA | NT5C | ENSPPYP00000002054 | ENSPPYP00000009679 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 5', 3'-nucleotidase, cytosolic. | 0.910 |
| CDA | NT5C2 | ENSPPYP00000002054 | ENSPPYP00000003045 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). Belongs to the 5'(3')-deoxyribonucleotidase family. | 0.912 |
| CDA | NT5DC4 | ENSPPYP00000002054 | ENSPPYP00000013570 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | NT5DC4 isoform 1. | 0.907 |
| CMPK1 | CDA | ENSPPYP00000001599 | ENSPPYP00000002054 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.413 |
| CMPK1 | DCK | ENSPPYP00000001599 | ENSPPYP00000016543 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxycytidine kinase. | 0.942 |
| CMPK1 | DCTD | ENSPPYP00000001599 | ENSPPYP00000017005 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.927 |
| CMPK1 | DCTPP1 | ENSPPYP00000001599 | ENSPPYP00000008220 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. | 0.904 |
| CMPK1 | DGUOK | ENSPPYP00000001599 | ENSPPYP00000013701 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | DGUOK isoform 2. | 0.451 |
| CMPK1 | NT5C | ENSPPYP00000001599 | ENSPPYP00000009679 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 5', 3'-nucleotidase, cytosolic. | 0.930 |
