GC protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

GC

GC isoform 2. (493 aa)

Predicted Functional Partners:

CUBN

0.946

AHSG

0.927

APOH

0.911

HPX

0.890

F2

0.869

FGB

0.861

TTR

0.860

CDCP2

0.827

SLC4A4

0.814

ACTA1

0.799

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Export your current network:

... as a bitmap image:

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file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

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same PNG format, but at higher resolution

... as a vector graphic:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA1	GC	ENSPPYP00000000129	ENSPPYP00000016545	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	GC isoform 2.	0.799
AHSG	APOH	ENSPPYP00000016086	ENSPPYP00000009611	Alpha 2-HS glycoprotein.	APOH isoform 1.	0.955
AHSG	F2	ENSPPYP00000016086	ENSPPYP00000003807	Alpha 2-HS glycoprotein.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.963
AHSG	FGB	ENSPPYP00000016086	ENSPPYP00000016918	Alpha 2-HS glycoprotein.	FGB isoform 1.	0.896
AHSG	GC	ENSPPYP00000016086	ENSPPYP00000016545	Alpha 2-HS glycoprotein.	GC isoform 2.	0.927
AHSG	HPX	ENSPPYP00000016086	ENSPPYP00000004063	Alpha 2-HS glycoprotein.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.771
AHSG	TTR	ENSPPYP00000016086	ENSPPYP00000010206	Alpha 2-HS glycoprotein.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family.	0.688
APOH	AHSG	ENSPPYP00000009611	ENSPPYP00000016086	APOH isoform 1.	Alpha 2-HS glycoprotein.	0.955
APOH	F2	ENSPPYP00000009611	ENSPPYP00000003807	APOH isoform 1.	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	0.951
APOH	FGB	ENSPPYP00000009611	ENSPPYP00000016918	APOH isoform 1.	FGB isoform 1.	0.715
APOH	GC	ENSPPYP00000009611	ENSPPYP00000016545	APOH isoform 1.	GC isoform 2.	0.911
APOH	HPX	ENSPPYP00000009611	ENSPPYP00000004063	APOH isoform 1.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.796
APOH	TTR	ENSPPYP00000009611	ENSPPYP00000010206	APOH isoform 1.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family.	0.473
CDCP2	GC	ENSPPYP00000001537	ENSPPYP00000016545	CDCP2 isoform 2.	GC isoform 2.	0.827
CUBN	GC	ENSPPYP00000002460	ENSPPYP00000016545	CUBN isoform 1.	GC isoform 2.	0.946
CUBN	TTR	ENSPPYP00000002460	ENSPPYP00000010206	CUBN isoform 1.	Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family.	0.456
F2	AHSG	ENSPPYP00000003807	ENSPPYP00000016086	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	Alpha 2-HS glycoprotein.	0.963
F2	APOH	ENSPPYP00000003807	ENSPPYP00000009611	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	APOH isoform 1.	0.951
F2	FGB	ENSPPYP00000003807	ENSPPYP00000016918	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	FGB isoform 1.	0.982
F2	GC	ENSPPYP00000003807	ENSPPYP00000016545	Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).	GC isoform 2.	0.869