node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN2L | DDX6 | ENSPPYP00000023544 | ENSPPYP00000004516 | ATXN2L isoform 2. | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | 0.814 |
ATXN2L | G3BP1 | ENSPPYP00000023544 | ENSPPYP00000017869 | ATXN2L isoform 2. | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | 0.801 |
ATXN2L | G3BP2 | ENSPPYP00000023544 | ENSPPYP00000016578 | ATXN2L isoform 2. | Ras GTPase-activating protein-binding protein 2; Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. | 0.894 |
ATXN2L | NUFIP2 | ENSPPYP00000023544 | ENSPPYP00000009131 | ATXN2L isoform 2. | NUFIP2 isoform 1. | 0.889 |
ATXN2L | PABPC1 | ENSPPYP00000023544 | ENSPPYP00000021076 | ATXN2L isoform 2. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.657 |
CAPRIN1 | DDX6 | ENSPPYP00000024685 | ENSPPYP00000004516 | CAPRIN1 isoform 1. | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | 0.554 |
CAPRIN1 | FMR1 | ENSPPYP00000024685 | ENSPPYP00000023279 | CAPRIN1 isoform 1. | Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] | 0.754 |
CAPRIN1 | G3BP1 | ENSPPYP00000024685 | ENSPPYP00000017869 | CAPRIN1 isoform 1. | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | 0.984 |
CAPRIN1 | G3BP2 | ENSPPYP00000024685 | ENSPPYP00000016578 | CAPRIN1 isoform 1. | Ras GTPase-activating protein-binding protein 2; Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. | 0.968 |
CAPRIN1 | NUFIP2 | ENSPPYP00000024685 | ENSPPYP00000009131 | CAPRIN1 isoform 1. | NUFIP2 isoform 1. | 0.574 |
CAPRIN1 | PABPC1 | ENSPPYP00000024685 | ENSPPYP00000021076 | CAPRIN1 isoform 1. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.595 |
CAPRIN1 | USP10 | ENSPPYP00000024685 | ENSPPYP00000008586 | CAPRIN1 isoform 1. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.660 |
DDX6 | ATXN2L | ENSPPYP00000004516 | ENSPPYP00000023544 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | ATXN2L isoform 2. | 0.814 |
DDX6 | CAPRIN1 | ENSPPYP00000004516 | ENSPPYP00000024685 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | CAPRIN1 isoform 1. | 0.554 |
DDX6 | FMR1 | ENSPPYP00000004516 | ENSPPYP00000023279 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] | 0.615 |
DDX6 | G3BP1 | ENSPPYP00000004516 | ENSPPYP00000017869 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | 0.745 |
DDX6 | G3BP2 | ENSPPYP00000004516 | ENSPPYP00000016578 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | Ras GTPase-activating protein-binding protein 2; Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. | 0.678 |
DDX6 | NUFIP2 | ENSPPYP00000004516 | ENSPPYP00000009131 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | NUFIP2 isoform 1. | 0.888 |
DDX6 | PABPC1 | ENSPPYP00000004516 | ENSPPYP00000021076 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping. | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] | 0.801 |
FMR1 | CAPRIN1 | ENSPPYP00000023279 | ENSPPYP00000024685 | Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] | CAPRIN1 isoform 1. | 0.754 |