| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1C8P | HPGDS | ENSPPYP00000002377 | ENSPPYP00000016678 | Prostaglandin F synthase 1-like isoform X1. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.917 |
| GSTO1 | HPGDS | ENSPPYP00000003064 | ENSPPYP00000016678 | Glutathione S-transferase omega 1. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.932 |
| GSTO1 | LOC100461022 | ENSPPYP00000003064 | ENSPPYP00000013395 | Glutathione S-transferase omega 1. | GSTT2B isoform 1; Belongs to the GST superfamily. | 0.833 |
| HPGDS | AKR1C8P | ENSPPYP00000016678 | ENSPPYP00000002377 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin F synthase 1-like isoform X1. | 0.917 |
| HPGDS | GSTO1 | ENSPPYP00000016678 | ENSPPYP00000003064 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Glutathione S-transferase omega 1. | 0.932 |
| HPGDS | LOC100461022 | ENSPPYP00000016678 | ENSPPYP00000013395 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | GSTT2B isoform 1; Belongs to the GST superfamily. | 0.921 |
| HPGDS | PTGES | ENSPPYP00000016678 | ENSPPYP00000022060 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase. | 0.926 |
| HPGDS | PTGES2 | ENSPPYP00000016678 | ENSPPYP00000022012 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase 2. | 0.927 |
| HPGDS | PTGES3 | ENSPPYP00000016678 | ENSPPYP00000005319 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.927 |
| HPGDS | PTGIS | ENSPPYP00000016678 | ENSPPYP00000012422 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. | 0.938 |
| HPGDS | PTGS1 | ENSPPYP00000016678 | ENSPPYP00000021934 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | PTGS1 isoform 4. | 0.935 |
| HPGDS | PTGS2 | ENSPPYP00000016678 | ENSPPYP00000000462 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | PTGS2 isoform 1. | 0.919 |
| HPGDS | TBXAS1 | ENSPPYP00000016678 | ENSPPYP00000020255 | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. | 0.930 |
| LOC100461022 | GSTO1 | ENSPPYP00000013395 | ENSPPYP00000003064 | GSTT2B isoform 1; Belongs to the GST superfamily. | Glutathione S-transferase omega 1. | 0.833 |
| LOC100461022 | HPGDS | ENSPPYP00000013395 | ENSPPYP00000016678 | GSTT2B isoform 1; Belongs to the GST superfamily. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.921 |
| PTGES | HPGDS | ENSPPYP00000022060 | ENSPPYP00000016678 | Prostaglandin E synthase. | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. | 0.926 |
| PTGES | PTGES2 | ENSPPYP00000022060 | ENSPPYP00000022012 | Prostaglandin E synthase. | Prostaglandin E synthase 2. | 0.961 |
| PTGES | PTGES3 | ENSPPYP00000022060 | ENSPPYP00000005319 | Prostaglandin E synthase. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. | 0.971 |
| PTGES | PTGIS | ENSPPYP00000022060 | ENSPPYP00000012422 | Prostaglandin E synthase. | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. | 0.945 |
| PTGES | PTGS1 | ENSPPYP00000022060 | ENSPPYP00000021934 | Prostaglandin E synthase. | PTGS1 isoform 4. | 0.945 |
