METAP1 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBWD1	METAP1	ENSPPYP00000021577	ENSPPYP00000016687	CBWD2 isoform 1.	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.835
CBWD1	METAP2	ENSPPYP00000021577	ENSPPYP00000005526	CBWD2 isoform 1.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.462
CR201_G0028351	METAP1	ENSPPYP00000010281	ENSPPYP00000016687	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.833
CR201_G0028351	METAP2	ENSPPYP00000010281	ENSPPYP00000005526	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.669
CR201_G0028351	RPL11	ENSPPYP00000010281	ENSPPYP00000002010	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]	0.993
CR201_G0028351	RPL23	ENSPPYP00000010281	ENSPPYP00000009553	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.995
CR201_G0028351	RPL8	ENSPPYP00000010281	ENSPPYP00000021297	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.	0.994
CR201_G0028351	RPS11	ENSPPYP00000010281	ENSPPYP00000023489	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	RPS11 isoform 3; Belongs to the universal ribosomal protein uS17 family.	0.984
CR201_G0028351	RPS5	ENSPPYP00000010281	ENSPPYP00000024669	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	RPS5 isoform 1; Belongs to the universal ribosomal protein uS7 family.	0.983
CR201_G0028351	RPS9	ENSPPYP00000010281	ENSPPYP00000011623	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.	0.984
ENSPPYP00000014598	METAP1	ENSPPYP00000014598	ENSPPYP00000016687	annotation not available	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.833
ENSPPYP00000014598	METAP2	ENSPPYP00000014598	ENSPPYP00000005526	annotation not available	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.669
ENSPPYP00000014598	RPL11	ENSPPYP00000014598	ENSPPYP00000002010	annotation not available	60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]	0.993
ENSPPYP00000014598	RPL23	ENSPPYP00000014598	ENSPPYP00000009553	annotation not available	60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.996
ENSPPYP00000014598	RPL8	ENSPPYP00000014598	ENSPPYP00000021297	annotation not available	60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.	0.994
ENSPPYP00000014598	RPS11	ENSPPYP00000014598	ENSPPYP00000023489	annotation not available	RPS11 isoform 3; Belongs to the universal ribosomal protein uS17 family.	0.984
ENSPPYP00000014598	RPS5	ENSPPYP00000014598	ENSPPYP00000024669	annotation not available	RPS5 isoform 1; Belongs to the universal ribosomal protein uS7 family.	0.983
ENSPPYP00000014598	RPS9	ENSPPYP00000014598	ENSPPYP00000011623	annotation not available	Ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.	0.984
METAP1	CBWD1	ENSPPYP00000016687	ENSPPYP00000021577	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	CBWD2 isoform 1.	0.835
METAP1	CR201_G0028351	ENSPPYP00000016687	ENSPPYP00000010281	Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	RPL17-C18orf32 isoform 3; Belongs to the universal ribosomal protein uL22 family.	0.833