| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAA1 | ACAT1 | ENSPPYP00000015674 | ENSPPYP00000004400 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.922 |
| ACAA1 | ACAT2 | ENSPPYP00000015674 | ENSPPYP00000019199 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.916 |
| ACAA1 | ECHDC2 | ENSPPYP00000015674 | ENSPPYP00000001559 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.686 |
| ACAA1 | ECHS1 | ENSPPYP00000015674 | ENSPPYP00000003261 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | 0.844 |
| ACAA1 | EHHADH | ENSPPYP00000015674 | ENSPPYP00000016064 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.994 |
| ACAA1 | HADH | ENSPPYP00000015674 | ENSPPYP00000016738 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase. | 0.992 |
| ACAA1 | HADHA | ENSPPYP00000015674 | ENSPPYP00000014051 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.990 |
| ACAA1 | HADHB | ENSPPYP00000015674 | ENSPPYP00000014050 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.923 |
| ACAA1 | HSD17B10 | ENSPPYP00000015674 | ENSPPYP00000023949 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.966 |
| ACAA1 | OXCT1 | ENSPPYP00000015674 | ENSPPYP00000017238 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.640 |
| ACAT1 | ACAA1 | ENSPPYP00000004400 | ENSPPYP00000015674 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.922 |
| ACAT1 | ACAT2 | ENSPPYP00000004400 | ENSPPYP00000019199 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.930 |
| ACAT1 | ECHDC2 | ENSPPYP00000004400 | ENSPPYP00000001559 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.595 |
| ACAT1 | ECHS1 | ENSPPYP00000004400 | ENSPPYP00000003261 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | 0.764 |
| ACAT1 | EHHADH | ENSPPYP00000004400 | ENSPPYP00000016064 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.970 |
| ACAT1 | HADH | ENSPPYP00000004400 | ENSPPYP00000016738 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase. | 0.989 |
| ACAT1 | HADHA | ENSPPYP00000004400 | ENSPPYP00000014051 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.982 |
| ACAT1 | HADHB | ENSPPYP00000004400 | ENSPPYP00000014050 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.958 |
| ACAT1 | HSD17B10 | ENSPPYP00000004400 | ENSPPYP00000023949 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.588 |
| ACAT1 | OXCT1 | ENSPPYP00000004400 | ENSPPYP00000017238 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.976 |
