| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC1 | ANAPC10 | ENSPPYP00000013557 | ENSPPYP00000016864 | ANAPC1 isoform 2. | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | 0.998 |
| ANAPC1 | BUB1 | ENSPPYP00000013557 | ENSPPYP00000013551 | ANAPC1 isoform 2. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.866 |
| ANAPC1 | BUB1B | ENSPPYP00000013557 | ENSPPYP00000007185 | ANAPC1 isoform 2. | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | 0.992 |
| ANAPC1 | BUB3 | ENSPPYP00000013557 | ENSPPYP00000003192 | ANAPC1 isoform 2. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.979 |
| ANAPC1 | CDC16 | ENSPPYP00000013557 | ENSPPYP00000006309 | ANAPC1 isoform 2. | CDC16 isoform 4. | 0.998 |
| ANAPC1 | CDC20 | ENSPPYP00000013557 | ENSPPYP00000001678 | ANAPC1 isoform 2. | Cell division cycle 20. | 0.994 |
| ANAPC1 | CDC27 | ENSPPYP00000013557 | ENSPPYP00000010040 | ANAPC1 isoform 2. | CDC27 isoform 1. | 0.998 |
| ANAPC1 | CDK1 | ENSPPYP00000013557 | ENSPPYP00000002808 | ANAPC1 isoform 2. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.901 |
| ANAPC1 | MAD1L1 | ENSPPYP00000013557 | ENSPPYP00000019395 | ANAPC1 isoform 2. | Mitotic arrest deficient 1 like 1. | 0.682 |
| ANAPC1 | MAD2L1 | ENSPPYP00000013557 | ENSPPYP00000016788 | ANAPC1 isoform 2. | MAD2L1 isoform 1. | 0.989 |
| ANAPC10 | ANAPC1 | ENSPPYP00000016864 | ENSPPYP00000013557 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | ANAPC1 isoform 2. | 0.998 |
| ANAPC10 | BUB1 | ENSPPYP00000016864 | ENSPPYP00000013551 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.815 |
| ANAPC10 | BUB1B | ENSPPYP00000016864 | ENSPPYP00000007185 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. | 0.989 |
| ANAPC10 | BUB3 | ENSPPYP00000016864 | ENSPPYP00000003192 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] | 0.914 |
| ANAPC10 | CDC16 | ENSPPYP00000016864 | ENSPPYP00000006309 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | CDC16 isoform 4. | 0.998 |
| ANAPC10 | CDC20 | ENSPPYP00000016864 | ENSPPYP00000001678 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | Cell division cycle 20. | 0.993 |
| ANAPC10 | CDC27 | ENSPPYP00000016864 | ENSPPYP00000010040 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | CDC27 isoform 1. | 0.998 |
| ANAPC10 | CDK1 | ENSPPYP00000016864 | ENSPPYP00000002808 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] | 0.820 |
| ANAPC10 | MAD1L1 | ENSPPYP00000016864 | ENSPPYP00000019395 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | Mitotic arrest deficient 1 like 1. | 0.655 |
| ANAPC10 | MAD2L1 | ENSPPYP00000016864 | ENSPPYP00000016788 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. | MAD2L1 isoform 1. | 0.992 |
