node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF2 | IL1A | ENSPPYP00000017620 | ENSPPYP00000013572 | Colony stimulating factor 2. | Interleukin-1; Belongs to the IL-1 family. | 0.944 |
CSF2 | IL1B | ENSPPYP00000017620 | ENSPPYP00000013573 | Colony stimulating factor 2. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.910 |
CSF2 | IL2 | ENSPPYP00000017620 | ENSPPYP00000016803 | Colony stimulating factor 2. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.946 |
CSF2 | IL2RA | ENSPPYP00000017620 | ENSPPYP00000002390 | Colony stimulating factor 2. | Interleukin 2 receptor subunit alpha. | 0.855 |
CSF2 | IL2RB | ENSPPYP00000017620 | ENSPPYP00000013151 | Colony stimulating factor 2. | IL2RB isoform 1. | 0.540 |
CSF2 | IL2RG | ENSPPYP00000017620 | ENSPPYP00000022888 | Colony stimulating factor 2. | IL2RG isoform 2. | 0.780 |
CSF2 | IL4 | ENSPPYP00000017620 | ENSPPYP00000017632 | Colony stimulating factor 2. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.807 |
CSF2 | IL5 | ENSPPYP00000017620 | ENSPPYP00000017629 | Colony stimulating factor 2. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.886 |
CSF2 | IL6 | ENSPPYP00000017620 | ENSPPYP00000019884 | Colony stimulating factor 2. | IL6 isoform 2. | 0.778 |
CSF2 | JAK1 | ENSPPYP00000017620 | ENSPPYP00000001481 | Colony stimulating factor 2. | Tyrosine-protein kinase. | 0.587 |
IL1A | CSF2 | ENSPPYP00000013572 | ENSPPYP00000017620 | Interleukin-1; Belongs to the IL-1 family. | Colony stimulating factor 2. | 0.944 |
IL1A | IL1B | ENSPPYP00000013572 | ENSPPYP00000013573 | Interleukin-1; Belongs to the IL-1 family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.999 |
IL1A | IL2 | ENSPPYP00000013572 | ENSPPYP00000016803 | Interleukin-1; Belongs to the IL-1 family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. | 0.943 |
IL1A | IL2RA | ENSPPYP00000013572 | ENSPPYP00000002390 | Interleukin-1; Belongs to the IL-1 family. | Interleukin 2 receptor subunit alpha. | 0.473 |
IL1A | IL2RG | ENSPPYP00000013572 | ENSPPYP00000022888 | Interleukin-1; Belongs to the IL-1 family. | IL2RG isoform 2. | 0.406 |
IL1A | IL4 | ENSPPYP00000013572 | ENSPPYP00000017632 | Interleukin-1; Belongs to the IL-1 family. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. | 0.853 |
IL1A | IL5 | ENSPPYP00000013572 | ENSPPYP00000017629 | Interleukin-1; Belongs to the IL-1 family. | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. | 0.718 |
IL1A | IL6 | ENSPPYP00000013572 | ENSPPYP00000019884 | Interleukin-1; Belongs to the IL-1 family. | IL6 isoform 2. | 0.861 |
IL1A | JAK1 | ENSPPYP00000013572 | ENSPPYP00000001481 | Interleukin-1; Belongs to the IL-1 family. | Tyrosine-protein kinase. | 0.424 |
IL1B | CSF2 | ENSPPYP00000013573 | ENSPPYP00000017620 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Colony stimulating factor 2. | 0.910 |