NUDT6 protein (Pongo abelii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NUDT6

NUDT6 isoform 2. (295 aa)

Predicted Functional Partners:

HDGF

0.574

FGF2

0.510

SPATA5

0.503

FGF13

0.462

SPRED2

0.457

SPRED3

0.455

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF13	HDGF	ENSPPYP00000023260	ENSPPYP00000000814	Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...]	Heparin binding growth factor.	0.501
FGF13	NUDT6	ENSPPYP00000023260	ENSPPYP00000016810	Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...]	NUDT6 isoform 2.	0.462
FGF2	HDGF	ENSPPYP00000016808	ENSPPYP00000000814	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Heparin binding growth factor.	0.580
FGF2	NUDT6	ENSPPYP00000016808	ENSPPYP00000016810	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NUDT6 isoform 2.	0.510
HDGF	FGF13	ENSPPYP00000000814	ENSPPYP00000023260	Heparin binding growth factor.	Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...]	0.501
HDGF	FGF2	ENSPPYP00000000814	ENSPPYP00000016808	Heparin binding growth factor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.580
HDGF	NUDT6	ENSPPYP00000000814	ENSPPYP00000016810	Heparin binding growth factor.	NUDT6 isoform 2.	0.574
NUDT6	FGF13	ENSPPYP00000016810	ENSPPYP00000023260	NUDT6 isoform 2.	Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...]	0.462
NUDT6	FGF2	ENSPPYP00000016810	ENSPPYP00000016808	NUDT6 isoform 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.510
NUDT6	HDGF	ENSPPYP00000016810	ENSPPYP00000000814	NUDT6 isoform 2.	Heparin binding growth factor.	0.574
NUDT6	SPATA5	ENSPPYP00000016810	ENSPPYP00000016811	NUDT6 isoform 2.	SPATA5 isoform 1.	0.503
NUDT6	SPRED2	ENSPPYP00000016810	ENSPPYP00000013781	NUDT6 isoform 2.	Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.	0.457
NUDT6	SPRED3	ENSPPYP00000016810	ENSPPYP00000011121	NUDT6 isoform 2.	Sprouty related EVH1 domain containing 3.	0.455
SPATA5	NUDT6	ENSPPYP00000016811	ENSPPYP00000016810	SPATA5 isoform 1.	NUDT6 isoform 2.	0.503
SPATA5	SPRED2	ENSPPYP00000016811	ENSPPYP00000013781	SPATA5 isoform 1.	Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.	0.457
SPATA5	SPRED3	ENSPPYP00000016811	ENSPPYP00000011121	SPATA5 isoform 1.	Sprouty related EVH1 domain containing 3.	0.448
SPRED2	NUDT6	ENSPPYP00000013781	ENSPPYP00000016810	Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.	NUDT6 isoform 2.	0.457
SPRED2	SPATA5	ENSPPYP00000013781	ENSPPYP00000016811	Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.	SPATA5 isoform 1.	0.457
SPRED3	NUDT6	ENSPPYP00000011121	ENSPPYP00000016810	Sprouty related EVH1 domain containing 3.	NUDT6 isoform 2.	0.455
SPRED3	SPATA5	ENSPPYP00000011121	ENSPPYP00000016811	Sprouty related EVH1 domain containing 3.	SPATA5 isoform 1.	0.448