| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BOLA3 | NUDT6 | ENSPPYP00000013699 | ENSPPYP00000016810 | BolA family member 3; Belongs to the BolA/IbaG family. | NUDT6 isoform 2. | 0.762 |
| NUDT12 | NUDT14 | ENSPPYP00000017521 | ENSPPYP00000007047 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | NUDT14 isoform 3. | 0.604 |
| NUDT12 | NUDT17 | ENSPPYP00000017521 | ENSPPYP00000001088 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | Nudix hydrolase 17. | 0.511 |
| NUDT12 | NUDT18 | ENSPPYP00000017521 | ENSPPYP00000020633 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | Nudix hydrolase 18; Belongs to the Nudix hydrolase family. | 0.729 |
| NUDT12 | NUDT21 | ENSPPYP00000017521 | ENSPPYP00000008319 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] | 0.525 |
| NUDT12 | NUDT22 | ENSPPYP00000017521 | ENSPPYP00000003599 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | NUDT22 isoform 6. | 0.583 |
| NUDT12 | NUDT3 | ENSPPYP00000017521 | ENSPPYP00000018468 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | Diphosphoinositol polyphosphate phosphohydrolase 1. | 0.545 |
| NUDT12 | NUDT5 | ENSPPYP00000017521 | ENSPPYP00000002427 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place w [...] | 0.603 |
| NUDT12 | NUDT6 | ENSPPYP00000017521 | ENSPPYP00000016810 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | NUDT6 isoform 2. | 0.528 |
| NUDT14 | NUDT12 | ENSPPYP00000007047 | ENSPPYP00000017521 | NUDT14 isoform 3. | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | 0.604 |
| NUDT14 | NUDT17 | ENSPPYP00000007047 | ENSPPYP00000001088 | NUDT14 isoform 3. | Nudix hydrolase 17. | 0.712 |
| NUDT14 | NUDT18 | ENSPPYP00000007047 | ENSPPYP00000020633 | NUDT14 isoform 3. | Nudix hydrolase 18; Belongs to the Nudix hydrolase family. | 0.717 |
| NUDT14 | NUDT21 | ENSPPYP00000007047 | ENSPPYP00000008319 | NUDT14 isoform 3. | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] | 0.543 |
| NUDT14 | NUDT22 | ENSPPYP00000007047 | ENSPPYP00000003599 | NUDT14 isoform 3. | NUDT22 isoform 6. | 0.665 |
| NUDT14 | NUDT3 | ENSPPYP00000007047 | ENSPPYP00000018468 | NUDT14 isoform 3. | Diphosphoinositol polyphosphate phosphohydrolase 1. | 0.532 |
| NUDT14 | NUDT5 | ENSPPYP00000007047 | ENSPPYP00000002427 | NUDT14 isoform 3. | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place w [...] | 0.687 |
| NUDT14 | NUDT6 | ENSPPYP00000007047 | ENSPPYP00000016810 | NUDT14 isoform 3. | NUDT6 isoform 2. | 0.533 |
| NUDT17 | NUDT12 | ENSPPYP00000001088 | ENSPPYP00000017521 | Nudix hydrolase 17. | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. | 0.511 |
| NUDT17 | NUDT14 | ENSPPYP00000001088 | ENSPPYP00000007047 | Nudix hydrolase 17. | NUDT14 isoform 3. | 0.712 |
| NUDT17 | NUDT18 | ENSPPYP00000001088 | ENSPPYP00000020633 | Nudix hydrolase 17. | Nudix hydrolase 18; Belongs to the Nudix hydrolase family. | 0.712 |
