TLR2 protein (Pongo abelii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Knowledge-based Evidence

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	TLR1	ENSPPYP00000017732	ENSPPYP00000016387	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.490
CD14	TLR2	ENSPPYP00000017732	ENSPPYP00000016910	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor.	0.977
CD14	TLR4	ENSPPYP00000017732	ENSPPYP00000021908	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.973
CD14	TLR6	ENSPPYP00000017732	ENSPPYP00000016388	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor.	0.489
HMGB1	NFKB1	ENSPPYP00000006318	ENSPPYP00000016712	High mobility group box 1.	Nuclear factor kappa B subunit 1.	0.522
HMGB1	RELA	ENSPPYP00000006318	ENSPPYP00000003533	High mobility group box 1.	RELA proto-oncogene, NF-kB subunit.	0.446
HMGB1	TLR2	ENSPPYP00000006318	ENSPPYP00000016910	High mobility group box 1.	Toll-like receptor.	0.948
HMGB1	TLR4	ENSPPYP00000006318	ENSPPYP00000021908	High mobility group box 1.	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.989
MYD88	NFKB1	ENSPPYP00000015673	ENSPPYP00000016712	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Nuclear factor kappa B subunit 1.	0.875
MYD88	RELA	ENSPPYP00000015673	ENSPPYP00000003533	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	RELA proto-oncogene, NF-kB subunit.	0.638
MYD88	TIRAP	ENSPPYP00000015673	ENSPPYP00000004627	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TIR domain containing adaptor protein.	0.996
MYD88	TLR1	ENSPPYP00000015673	ENSPPYP00000016387	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll like receptor 1; Belongs to the Toll-like receptor family.	0.985
MYD88	TLR2	ENSPPYP00000015673	ENSPPYP00000016910	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor.	0.991
MYD88	TLR4	ENSPPYP00000015673	ENSPPYP00000021908	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	TLR4 isoform 1; Belongs to the Toll-like receptor family.	0.997
MYD88	TLR6	ENSPPYP00000015673	ENSPPYP00000016388	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll-like receptor.	0.983
MYD88	TOLLIP	ENSPPYP00000015673	ENSPPYP00000003370	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Toll interacting protein.	0.956
NFKB1	HMGB1	ENSPPYP00000016712	ENSPPYP00000006318	Nuclear factor kappa B subunit 1.	High mobility group box 1.	0.522
NFKB1	MYD88	ENSPPYP00000016712	ENSPPYP00000015673	Nuclear factor kappa B subunit 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.875
NFKB1	RELA	ENSPPYP00000016712	ENSPPYP00000003533	Nuclear factor kappa B subunit 1.	RELA proto-oncogene, NF-kB subunit.	0.999
NFKB1	TIRAP	ENSPPYP00000016712	ENSPPYP00000004627	Nuclear factor kappa B subunit 1.	TIR domain containing adaptor protein.	0.412